Myosmine
(Synonyms: 麦斯明) 目录号 : GC14588
A minor tobacco alkaloid
Cas No.:532-12-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine [1][3][4].
Myosmine is a specific tobacco alkaloid. It is found in a variety of other plants such as maize, rice, wheat flour, millet, potato, and milk and also cocoa, popcorn, tomato, carrot, pineapple, kiwi, and apples. Myosmine is easily nitrosated, yielding 4-hy-droxy-1-(3-pyridyl)-1-butanone (HPB) and a DNA adduct identical to the esophageal tobacco carcinogen N-nitrosonornicotine [2][4].
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. Nicotine is the addictive active ingredient in tobacco smoke that acts as an agonist at neuronal nicotinic acetylcholine receptors with Ki values of 480.69 and 11.13 nM for α3β4 and α4β2 subtypes, respectively [2]. Myosmine weakly binds to a4β2 nACh receptors with Ki value of 3.3 μM [3].
In rats treated with combinations of myosmine and NaNO2, no evidence showed the production of HPB-releasing Hb and DNA adducts, suggesting that exposure to dietary myosmine couldn’t lead to HPB-releasing DNA or Hb adducts in humans [5].
References:
[1]. Tyroller S, Zwickenpflug W, Richter E. New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. J Agric Food Chem. 2002 Aug 14;50(17):4909-15.
[2]. Zaveri N, Jiang F, Olsen C, et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem. 2010 Nov 25;53(22):8187-91.
[3]. Ferretti G1, Dukat M, Giannella M, et al. Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5.
[4]. Zwickenpflug W, Tyroller S, Richter E. Metabolism of myosmine in Wistar rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.
[5]. Hecht SS, Han S, Kenney PM, et al. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chem Res Toxicol. 2007 Mar;20(3):543-9.
| Cas No. | 532-12-7 | SDF | |
| 别名 | 麦斯明 | ||
| 化学名 | 3-(3,4-dihydro-2H-pyrrol-5-yl)-pyridine | ||
| Canonical SMILES | C1(C2=NCCC2)=CC=CN=C1 | ||
| 分子式 | C9H10N2 | 分子量 | 146.2 |
| 溶解度 | ≥ 8.5mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.8399 mL | 34.1997 mL | 68.3995 mL |
| 5 mM | 1.368 mL | 6.8399 mL | 13.6799 mL |
| 10 mM | 0.684 mL | 3.42 mL | 6.8399 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。