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GHV (sodium salt)

(Synonyms: 钠4-羟基戊酯) 目录号 : GC45460

An Analytical Reference Standard

GHV (sodium salt) Chemical Structure

Cas No.:56279-37-9

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10mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

GHV (sodium salt) is an analytical reference standard categorized as a sedative.[1] GHV is an active metabolite of γ-valerolactone .[2] This product is intended for research and forensic applications.

References
[1]. Carter, L.P., Chen, W., Wu, H., et al. Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV). Drug Alcohol Depend. 78(1), 91-99 (2005).
[2]. Andresen-Streichert, H., Jungen, H., Gehl, A., et al. Uptake of gamma-valerolactone--detection of gamma-hydroxyvaleric acid in human urine samples. J. Anal. Toxicol. 37(4), 250-254 (2013).

Chemical Properties

Cas No. 56279-37-9 SDF
别名 钠4-羟基戊酯
化学名 4-hydroxy-pentanoic acid, monosodium salt
Canonical SMILES OC(CCC(O)C)=O.[Na+]
分子式 C5H10O3.Na 分子量 141.1
溶解度 Ethanol: 5mg/mL,PBS (pH 7.2): 10mg/mL 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 7.0872 mL 35.4359 mL 70.8717 mL
5 mM 1.4174 mL 7.0872 mL 14.1743 mL
10 mM 0.7087 mL 3.5436 mL 7.0872 mL
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Research Update

Characterization and pharmacology of the GHB receptor

Ann N Y Acad Sci 2008 Oct;1139:374-85.PMID:18991884DOI:10.1196/annals.1432.048

Radioligand binding using [(3)H]NCS-382, an antagonist of the GHB receptor, revealed specific binding sites in the rat cerebrocortical and hippocampal membranes. Scatchard analysis of saturation isotherms revealed two different populations of binding sites. NCS-382 was about 10 times more potent than GHB in inhibiting [(3)H]NCS-382 binding. A variety of ligands for other receptors did not affect [(3)H]NCS-382 binding. Quantitative autoradiographic analysis of [(3)H]NCS-382 binding revealed similar characteristics. Thus [(3)H]NCS-382, being more potent and selective, offers advantage over [(3)H]GHB as a radioligand. Unlike GHB, several analogues of GHB such as UMB68 (a tertiary alcohol analogue of GHB), UMB86 (4-hydroxy-4-napthylbutanoic acid, sodium salt), UMB72 [4-(3-phenylpropyloxy)butyric acid, sodium salt], UMB73 (4-benzyloxybutyric acid, sodium salt), UMB66 (3-chloropropanoic acid), gamma-hydroxyvaleric acid (that is, GHV, a 4-methyl-substituted analogue of GHB), 3-HPA (3-hydroxyphenylacetic acid), and ethers of 3-hydroxyphenylacetic acid (UMB108, UMB109, and UMB119) displaced [(3)H]NCS-382 without affecting [(3)H]GABA binding to GABA(B) receptor. Thus these compounds offer an advantage over GHB as an experimental tool. Our study, aimed at exploring the potential involvement of the GHB receptor in the pharmacology of ethanol, indicated that ethanol does not affect [(3)H]NCS-382 binding in the rat brain, thereby suggesting that ethanol does not interact directly with the GHB receptor. Our study, aimed at exploring the involvement of the GHB receptor in the pathology of succinate semialdehyde dehydrogenase deficiency, which is known to cause elevation of GHB levels, revealed no change in the affinity, receptor density or displacement potency as determined by using [(3)H]NCS-382 as a radioligand in Aldh5a1(-/-) vs. Aldh5a1(+/+) mouse brain.