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Mitoxantrone-d8 Sale

(Synonyms: 米托蒽醌-D8,Mitozantrone-d8; NSC 301739-d8) 目录号 : GC45998

An internal standard for the quantification of mitoxantrone

Mitoxantrone-d8 Chemical Structure

Cas No.:1189974-82-0

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1mg
¥4,266.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Mitoxantrone-d8 is intended for use as an internal standard for the quantification of mitoxantrone by GC- or LC-MS. Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation.1,2 It also inhibits HIV-1 integrase (IC50 = 3.8 μM).3 Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.5,6,7

|1. Fox, M.E., and Smith, P.J. Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone. Cancer Res. 50(18), 5813-5818 (1990).|2. Hasinoff, B.B., Liang, H., Wu, X., et al. The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorg. Med. Chem. 16(7), 3959-3968 (2008).|3. Carlson, H.A., Masukawa, K.M., Rubins, K., et al. Developing a dynamic pharmacophore model for HIV-1 integrase. J. Med. Chem. 43(111), 2100-2114 (2000).|4. Morrow, C.S., Peklak-Scott, C., Bishwokarma, B., et al. Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol. Pharmacol. 69(4), 1499-1505 (2006).|5. Garcia, J.A., and Rini, B.I. Castration-resistant prostate cancer: Many treatments, many options, many challenges ahead. Cancer 118(10), 2583-2593 (2012).|6. Lu, E., Wang, B.W., Guimond, C., et al. Safety of disease-modifying drugs for multiple sclerosis in pregnancy: Current challenges and future considerations for effective pharmacovigilance. Expert Rev. Neurother. 13(3), 251-260 (2013).|7. Marriott, J.J., Miyasaki, J.M., Gronseth, G., et al. Evidence report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis. Neurology 74(18), 1463-1470 (2010).

Chemical Properties

Cas No. 1189974-82-0 SDF
别名 米托蒽醌-D8,Mitozantrone-d8; NSC 301739-d8
Canonical SMILES O=C1C2=C(C(O)=CC=C2O)C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O
分子式 C22H20D8N4O6 分子量 452.5
溶解度 DMSO: soluble,Methanol: soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2099 mL 11.0497 mL 22.0994 mL
5 mM 0.442 mL 2.2099 mL 4.4199 mL
10 mM 0.221 mL 1.105 mL 2.2099 mL
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