LZTFL1 Human
目录号 : GP23855Leucine Zipper Transcription Factor-Like 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Leucine Zipper Transcription Factor-Like 1; BBS17; LeucineZipper Transcription Factor-Like Protein 1; Leucine zipper transcriptionfactor-like protein 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVEDTFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEFEKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEKALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMAEKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | LZTFL1 protein solution (1mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT. | ||
LeucineZipper Transcription Factor-Like 1, also known as LZTFL1 is a ubiquitouslyexpressed protein which localizes to the cytoplasm. LZTFL1 interacts with Bardet-BiedlSyndrome proteins (BBS) and during its interaction with BBS protein complexes,regulates protein trafficking to the ciliary membrane. Nonsense mutations inLZTFL1 cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized partlyby polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. LZTFL1 also acts as a tumorsuppressor; possibly by interacting with E-cadherin as well as the actin cytoskeletonand in this manner regulating the transition of epithelial cells to mesenchymalcells.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.