LUM Human
目录号 : GP23846Lumican 人类重组体
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Lumican; LDC; Lumican Proteoglycan; Keratan Sulfate Proteoglycan Lumican; SLRR2D; KSPG Lumican. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSQYYDYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLN. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | LUM protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. | ||
Lumicanalso known as LUM belongs to the small leucine-rich proteoglycan (SLRP) familywhich comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, andosteoglycin. Furthermore we can see that in these bifunctional molecules, theprotein moiety binds collagen fibrils and the highly charged hydrophilicglycosaminoglycans regulateinterfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM isalso distributed in interstitialcollagenous matrices throughout the body. Lumican regulates collagenfibril organization and circumferential growth, corneal transparency,epithelial cell migration and tissue repair. Among the diseases associated withLUM is posterior amorphous corneal dystrophy.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.