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γ-Linolenic Acid methyl ester Sale

(Synonyms: r-亚麻酸甲酯,Methyl GLA,Methyl γ-Linolenate) 目录号 : GC10020

A dietary ω-6 PUFA

γ-Linolenic Acid methyl ester Chemical Structure

Cas No.:16326-32-2

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50mg
¥262.00
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100mg
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250mg
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1g
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.

LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease.

In vitro: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM [1].

In vivo: In an in-vivo model of LTB4-induced bronchoconstriction, ricinelaidic acid andγ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Yagaloff, K. A.,Franco, L.,Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukotrienes and Essential Fatty Acids 52, 293-297 (1995).

Chemical Properties

Cas No. 16326-32-2 SDF
别名 r-亚麻酸甲酯,Methyl GLA,Methyl γ-Linolenate
化学名 6Z,9Z,12Z-octadecatrienoic acid, methyl ester
Canonical SMILES CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O
分子式 C19H32O2 分子量 292.5
溶解度 ≤100mg/ml in DMSO;100mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.4188 mL 17.094 mL 34.188 mL
5 mM 0.6838 mL 3.4188 mL 6.8376 mL
10 mM 0.3419 mL 1.7094 mL 3.4188 mL
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