LINGO1 Human
目录号 : GP23822Leucine Rich Repeat And Ig Domain Containing 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Leucine Rich Repeat And Ig Domain Containing 1; LRRN6A; Leucine-RichRepeat And Immunoglobulin Domain-Containing Protein 1; Leucine-Rich RepeatNeuronal Protein 1; Leucine Rich Repeat Neuronal 6A; LERN1; Leucine-RichRepeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-InteractingProtein 1; Leucine-Rich Repeat Neuronal Protein 6A; UNQ201; LERN1; Leucine-richrepeat and immunoglobulin-like domain-containing nogo receptor-interactingprotein 1. | ||
| Amino Acid Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVRHLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | LINGO1 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol. | ||
Leucine Rich Repeat And Ig Domain Containing 1, also known as Lingo1 isprimarily expressed in neuronal tissue, and most abundantly in the cortex. Inaddition, Lingo 1 is involved in the inhibition of axon regeneration all theway through a ternary complex formed with NgR1 (ligand-binding subunit) and p75(signal transducing subunit). The inhibitory action is accomplished throughRhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in thecentral nervous system. Furthermore, LINGO-1 inhibits oligodendrocyte precursordifferentiation as well as myelination, by a mechanism which also involvesactivation of RhoA, however it appears that it does not require 75 or NgR1.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.