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Latrunculin B

(Synonyms: 红海海绵素 B) 目录号 : GC17006

Inhibitor of actin polymerization

Latrunculin B Chemical Structure

Cas No.:76343-94-7

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产品描述

The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells. Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM).[1] The short-term effects of latrunculin B are comparable to those of latrunculin A, although latrunculin B is slightly less potent.[2] However, latrunculin B is gradually inactivated by serum so that induced changes are transient in the continued presence of the compound. For this reason, latrunculin B may have fewer unwanted effects than latrunculin A and may be preferred for short-term studies.

Reference:
[1]. Wakatsuki, T., Schwab, B., Thompson, N.C., et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. Journal of Cell Science 114, 1025-1036 (2000).
[2]. Spector, I., Schochet, N.R., Blasberger, D., et al. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. comparison with cytochalasin D. Cell Motility and the Cytoskeleton 13, 127-144 (1989).

Chemical Properties

Cas No. 76343-94-7 SDF
别名 红海海绵素 B
化学名 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Canonical SMILES C/C(CC/C=C\[C@@H](C)CC[C@@H]1C[C@@H]2C[C@@]([C@H]3N([H])C(SC3)=O)(O)O1)=C/C(O2)=O
分子式 C20H29NO5S 分子量 395.5
溶解度 ≤25mg/ml in DMSO; 25 mg/ml in Ethanol 储存条件 Store at -20°C,protect from light
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1 mM 2.5284 mL 12.6422 mL 25.2845 mL
5 mM 0.5057 mL 2.5284 mL 5.0569 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL
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