LAMTOR4 Human
目录号 : GP23797LAMTOR4 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Late Endosomal/Lysosomal Adaptor; MAPK And MTOR Activator4; C7orf59; Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4; Chromosome7 Open Reading Frame 59; Ragulator Complex Protein LAMTOR4; UPF0539 ProteinC7orf59; LAMTOR4. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELVSTACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | LAMTOR4 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. | ||
LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,which is a signaling complex promoting cell growth in response to growthfactors, energy levels, and amino acids. LAMTOR4 is activated by amino acids viaa mechanism which involves the lysosomal V-ATPase, the Ragulator functions as aguanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulatorand Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomeswhere it is sequentially activated.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.