L-Thyroxine sodium
(Synonyms: Levothyroxine sodium; T4 sodium) 目录号 : GC61010
A synthetic form of thyroxine
Cas No.:1955-3-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
L-Thyroxine is a synthetic form of the thyroid hormone thyroxine.1,2,3 In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice.1 It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism.2,3 Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.
1.Bowers, C.Y., Schally, A.V., Reynolds, G.A., et al.Interactions of L-thyroxine or L-triiodothyronine and thyrotropin-releasing factor on the release and synthesis of thyrotropin from the anterior pituitary gland of miceEndocrinology81(4)741-747(1967) 2.Fabris, N., Muzzioli, M., and Mocchegiani, E.Recovery of age-dependent immunological deterioration in Balb/c mice by short-term treatment with L-thyroxineMech. Ageing Dev.18(4)327-338(1982) 3.Fabris, N., and Mocchegiani, E.Endocrine control of thymic serum factor production in young-adult and old miceCell Immunol.91(2)325-335(1985)
| Cas No. | 1955-3-8 | SDF | |
| 别名 | Levothyroxine sodium; T4 sodium | ||
| Canonical SMILES | N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O | ||
| 分子式 | C15H10I4NNaO4 | 分子量 | 798.85 |
| 溶解度 | DMSO: 250 mg/mL (312.95 mM); Water: 14 mg/mL (17.53 mM; ultrasonic and adjust pH to 12 with NaOH) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2518 mL | 6.259 mL | 12.518 mL |
| 5 mM | 0.2504 mL | 1.2518 mL | 2.5036 mL |
| 10 mM | 0.1252 mL | 0.6259 mL | 1.2518 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Thermal stability of synthetic thyroid hormone l-thyroxine and L-Thyroxine sodium salt hydrate both pure and in pharmaceutical formulations
J Pharm Biomed Anal 2016 Jun 5;125:33-40.PMID:26999320DOI:10.1016/j.jpba.2016.03.026.
In this paper, the thermal stability of pure l-thyroxine (THY) and L-Thyroxine sodium salt hydrate (THYSS) vs. two pharmaceutical solid formulations commercialized on both Romanian and European market (with a content of 100μg, respectively 200μg THYSS per tablet) were investigated. In order to determine whether the presence of excipients affects the thermal stability of the active pharmaceutical ingredient (API), the preliminary study of thermal stability in air atmosphere was completed with an in-depth solid-state kinetic study. By kinetic analysis, the non-isothermal degradation of the selected active pharmaceutical ingredients vs. the solid formulation with strength of 200μg THYSS per tablet was investigated. Isoconversional methods (Kissinger-Akahira-Sunose, Flynn-Wall-Ozawa and Friedman) were employed for the estimation of activation energies values, at five different heating rates, β=5, 7, 10, 12 and 15°Cmin(-1). Also, a fourth method was applied in the processing of data, namely NPK, allowing an objective separation in the physical and chemical processes that contribute to the thermal degradation of the selected compounds. A discussion of thermal stability from the kinetic point of view is also presented.
[Comparative effects of desiccated thyroid gland and sodium salt of L-thyroxine in the treatment of hypothyroidism]
Pol Tyg Lek 1989 Aug;44(32-33):768-70.PMID:2701751doi
The studies comparing the actions of dried thyroid gland (Thyroideum-Polfa) with L-Thyroxine sodium (L-T4) were carried out in 20 female patients with hypothyroidism, including 19 patients with the primary hypothyroidism and 1 patient with hypothyroidism secondary to pituitary deficiency. Administration of the dried thyroid gland did not normalize blood serum T4 an TSH in any patient. Normal serum T4 or even slightly increased was achieved in all patients treated with L-T4. Serum TSH was normalized in 17 patients with the primary hypothyroidism. The following conclusions have been drawn: 1. Dried thyroid gland (Thyroideum-Polfa) is ineffective in the treatment of hypothyroidism. 2. Serum TSH remains elevated despite normal serum T3 in cases of the primary hypothyroidism with decreased serum T4 levels. 3. Sodium salt of L-thyroxine should be used for the treatment of hypothyroidism. 1-Triiodothyronine sodium may be used as an adjuvant therapy.