L Selectin Human
目录号 : GP23836L-selectin Human Recombinant
Sample solution is provided at 25 µL, 10mM.
Purity | Greater than 95% as determined by SDS-PAGE. Single band on Western Blot. | Source | Escherichia Coli. |
Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
Synonyms | L-selectin; Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62 antigen-like family member L; CD62L antigen; LAM1; LNHR; LSEL; CD62L; LYAM1; Leu-8; PLNHR; hLHRc; Lyam-1; L-Sel. | ||
Stability | Store at 4°C if entire vial will be used within 1-2 weeks.Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles. | ||
Formulation | L-Sel is supplied in 1x PBS and 50% Glycerol. |
L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin, which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells, which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
L-Selectin can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments.The biological activity of this product has not yet been tested.
Store at 4°C if entire vial will be used within 1-2 weeks.Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles.