KRT17 Human
目录号 : GP23772Cytokeratin 17 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Keratin 17; PCHC1; 39.1; CK-17; K17; PC2; PC; cytokeratin-17;Keratin 17 Epitope S1; Keratin 17 Epitope S2; Keratin 17 Epitope S4; Keratin;Type I Cytoskeletal 1; keratin-17; Cytokeratin-17; Keratin-17. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTTSIRQ FTSSSSIKGS SGLGGGSSRT SCRLSGGLGA GSCRLGSAGGLGSTLGGSSY SSCYSFGSGG GYGSSFGGVD GLLAGGEKAT MQNLNDRLAS YLDKVRALEE ANTELEVKIRDWYQRQAPGP ARDYSQYYRT IEELQNKILT ATVDNANILL QIDNARLAAD DFRTKFETEQ ALRLSVEADINGLRRVLDEL TLARADLEMQ IENLKEELAY LKKNHEEEMN ALRGQVGGEI NVEMDAAPGV DLSRILNEMRDQYEKMAEKN RKDAEDWFFS KTEELNREVA TNSELVQSGK SEISELRRTM QALEIELQSQ LSMKASLEGNLAETENRYCV QLSQIQGLIG SVEEQLAQLR CEMEQQNQEY KILLDVKTRL EQEIATYRRL LEGEDAHLTQYKKEPVTTRQ VRTIVEEVQD GKVISSREQV HQTTR | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | KRT17 protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH8.0), 10% glycerol and 0.4M Urea. | ||
Cytokeratin17 also known as KRT17 is a type I cytokeratin. KRT17 is found in nail beds,hair follicles, sebaceous glands, and other epidermal appendages. Mutations inKRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystomamultiplex. KRT17 takes part in the formation and maintenance of a variety ofskin appendages, particularly in determining shape and orientation of hair. KRT17also modulates the function of TNF-alpha in the precise context of haircycling. Moreover, KRT17 regulates protein synthesis and epithelial cell growthall through binding to the adapter protein SFN and by stimulating Akt/mTORpathway.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.