Isopropamide iodide
(Synonyms: 异丙碘胺) 目录号 : GC39571
Isopropamide iodide is a long-acting quaternary anticholinergic drug used in the treatment of peptic ulcer and other gastrointestinal disorders.
Cas No.:71-81-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Isopropamide iodide is a long-acting quaternary anticholinergic drug used in the treatment of peptic ulcer and other gastrointestinal disorders.
| Cas No. | 71-81-8 | SDF | |
| 别名 | 异丙碘胺 | ||
| Canonical SMILES | CC([N+](CCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(N)=O)(C(C)C)C)C.[I-] | ||
| 分子式 | C23H33IN2O | 分子量 | 480.43 |
| 溶解度 | DMSO: 250 mg/mL (520.37 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0815 mL | 10.4073 mL | 20.8147 mL |
| 5 mM | 0.4163 mL | 2.0815 mL | 4.1629 mL |
| 10 mM | 0.2081 mL | 1.0407 mL | 2.0815 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Spectrophotometric determination of trifluoperazine HCl and Isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods
J Pharm Biomed Anal 2001 Sep;26(2):203-10.PMID:11470197DOI:10.1016/s0731-7085(01)00428-9.
Two methods are presented for the simultaneous determination of trifluoperazine hydrochloride and Isopropamide iodide in binary mixture. The first method depends on second derivative ((2)D) ultraviolet spectrophotometry, with zero crossing and peak to base measurement. The second derivative amplitudes at 270.4 and 230.2 nm were selected for the assay of trifluoperazine hydrochloride and Isopropamide iodide, respectively. The second method depends on second derivative of the ratio spectra by division of the absorption spectrum of the binary mixture by a normalized spectrum of one of the components and then calculating the second derivative of the ratio spectrum. The second derivative of the ratio amplitudes at 257 and 228 nm were selected for the determination of trifluoperazine hydrochloride and Isopropamide iodide, respectively. The two proposed methods were successfully applied to the determination of the two drugs in laboratory prepared mixtures and in commercial tablets.
Spectrophotometric determination of Isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate
Drug Test Anal 2010 Apr;2(4):168-81.PMID:20376832DOI:10.1002/dta.113.
Four sensitive, selective and precise stability indicating methods for the determination of Isopropamide iodide (ISO) and trifluoperazine hydrochloride (TPZ) in their binary mixture and in presence of trifluoperazine oxidative degradate (OXD). Method A is a derivative spectrophotometric one, where ISO was determined by first derivative (D(1)) at 226.4 nm while TPZ was determined by second derivative (D(2)) at 270.2 nm. Method B is the first derivative of the ratio spectra (DD(1)) spectrophotometric method, ISO can be determined by measuring the peak amplitude at 227.4 nm using 5 microg mL(-1) of OXD as a divisor, while TPZ can be determined by measuring the peak amplitude at 249.2 and 261.4 nm using 15 microg mL(-1) of ISO as a divisor. Method C is the isoabsorptive spectrophotometric method. This method allows determination of ISO and TPZ in their binary mixture by measuring total concentration of ISO and TPZ at their isoabsorptive point at lambda(229.8) nm (Aiso1) while TPZ concentration alone can be determined at lambda(max) 311.2 nm, then ISO concentration can be determined by subtraction. On the same basis TPZ can be determined in presence of ISO and OXD, where OXD concentration alone was determined by measuring the peak amplitude at lambda(281.6) and lambda(309.4) nm while total concentration of TPZ and OXD was determined at their isoabsorptive points at (Aiso2 = 270.2 nm), (Aiso3 = 310.6 nm) and (Aiso4 = 331.8 nm) then TPZ concentration was determined by subtraction. Method D is the multivariate calibration techniques [the classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS)], using the information contained in the absorption spectra of ISO, TPZ and OXD mixtures. The selectivity of the proposed methods was checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of ISO and TPZ in pharmaceutical dosage form without interference from other dosage form additives and the results were statistically compared with the reported method.
Effect of isopropamide on response to oral cimetidine in patients with Zollinger--Ellison syndrome
Dig Dis Sci 1982 Apr;27(4):353-9.PMID:6121690DOI:10.1007/BF01296756.
Patients with Zollinger-Ellison syndrome whose gastric acid secretion or symptoms were not controlled by cimetidine in conventional dosage were selected for studies of responsiveness of their acid secretion to increasing doses of cimetidine, used either alone or in combination with a long-acting anticholinergic agent, Isopropamide iodide. Results indicate that in the group as a whole the suppression achieved with a 900-mg dose of cimetidine was not significantly better than that achieved with a 300-mg dose, although in individual cases this did not hold true. In individuals the combination of cimetidine and isopropamide was generally more effective in suppressing acid secretion than cimetidine alone, used either in the same dose as in the combination or in the next highest possible dosage. This was also true in the group as a whole, where combined therapy showed significant advantage over either drug alone in controlling acid secretion, in the third, fourth, and fifth hours following administration of the drugs. The data suggest that in the minority of patients not controlled by cimetidine 300-600 mg q6h per os, addition of isopropamide (20-40 mg/day) may be preferable to further increasing the dose of cimetidine.
Separation and determination of Isopropamide iodide in pharmaceutical formulations by reversed-phase ion-pair high-performance liquid chromatography
J Chromatogr 1986 Sep 24;366:321-8.PMID:2877999DOI:10.1016/s0021-9673(01)93479-x.
A stability-indicating determination for Isopropamide iodide, an anticholinergic quaternary ammonium drug, in several pharmaceutical dosage forms by reversed-phase ion-pair liquid chromatography is reported. The use of eluents containing both an amine as well as an alkylsulphonate proved to be very efficient for separating and determining quaternary ammonium drugs and related other basic drugs: adequate selectivity, excellent peak shape and good reproducibility (coefficient of variation, 1-2%) were obtained in a short analysis time.
Spectrophotometric determination of some pharmaceutical amides through charge-transfer complexation reactions
J Pharm Biomed Anal 1991;9(3):219-24.PMID:1678622DOI:10.1016/0731-7085(91)80150-8.
A spectrophotometric method is described for the assay of fenpipramide hydrochloride, Isopropamide iodide, trimethobenzamide hydrochloride, morphazinamide hydrochloride and tolazamide. The method is based on the formation of a charge-transfer complex between the drug as n-donor and iodine, a sigma-acceptor. The product exhibits absorption maxima at 295 and 365 nm; measurements are made at 365 nm for fenpipramide and at 295 nm for the other compounds. Beer's law is obeyed in a concentration range of 1-120 micrograms ml-1. The method is rapid, simple and sensitive and can be applied to the analysis of some commercial and laboratory prepared tablets without interference. A more detailed investigation of the complex was made with respect to its composition, association constant and free energy change.