Iodipamide (Adipiodone)
(Synonyms: 胆影酸,Adipiodone) 目录号 : GC33523
Iodipamide (Adipiodone) 是一种三碘化苯甲酸酯衍生物和离子二聚体造影剂，用于诊断成像。
Cas No.:606-17-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Iodipamide is a tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging.
[1]. NCIt
| Cas No. | 606-17-7 | SDF | |
| 别名 | 胆影酸,Adipiodone | ||
| Canonical SMILES | O=C(NC1=C(I)C(C(O)=O)=C(I)C=C1I)CCCCC(NC2=C(I)C(C(O)=O)=C(I)C=C2I)=O | ||
| 分子式 | C20H14I6N2O6 | 分子量 | 1139.76 |
| 溶解度 | DMSO : 125 mg/mL (109.67 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.8774 mL | 4.3869 mL | 8.7738 mL |
| 5 mM | 0.1755 mL | 0.8774 mL | 1.7548 mL |
| 10 mM | 0.0877 mL | 0.4387 mL | 0.8774 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The choleretic effect of Iodipamide
J Clin Invest 1975 Mar;55(3):528-35.PMID:1117066DOI:10.1172/JCI107959.
It is well established that a number of organic anions are excreted by the liver into bile in association with a marked increase in bile flow. Previous studies have shown that Iodipamide (3,3'-(adipoyl-diimino)bis[2,4,6-triiodobenzoic acid]), the radiographic contrast material used for intravenous cholangiography, is a potent choleretic. Experiments were performed in unanesthetized dogs to determine if the increased bile flow produced by Iodipamide is canalicular or ductular in origin, to quantitate the choleresis associated with Iodipamide and taurocholate excretion, and to correlate these findings with the results of in vitro studies in which the osmotic activities of Iodipamide and taurocholate in both isotonic saline and bile were determined. The plasma erythritol clearance increase linearly with the excretion of Iodipamide, indicating that Iodipamide stimulates canalicular bile flow. The choleretic potency of Iodipamide (22 ml/mmol) is approximately 3 times that of taurocholate (7.8 ml/mmol), yet the osmotic activity of Iodipamide in bile (1.5 mosmol/mmol) is only twice as great as that of taurocholate in bile (0.8 mosmol/mmol). It therefore appears that, per unit of effective osmotic solute secreted, Iodipamide carries more water into the bile canaliculi than does taurocholate.
Nondestructive evaluation by x-ray computed tomography of dialysate flow patterns in capillary dialyzers
ASAIO Trans 1988 Jul-Sep;34(3):794-9.PMID:3196601doi
It is hard to evaluate dialysate flow patterns inside the fiber bundle of capillary dialyzers. The current study describes a novel determination of dialysate flow by x-ray computed tomography. The authors did steady and nonsteady state tracer experiments with Adipiodone to observe the dialysate flow pattern in capillary dialyzers held vertically and horizontally. The hollow fibers were filled with paraffin to avoid permeation of Adipiodone from the dialysate to blood compartment. In steady state tracer experiments, Adipiodone solution (50 vol%) was injected into the dialysate compartment at a flow rate of 1.5 ml/min. Horizontal sectional dialysate flow patterns were observed every 2 cm from the point of the Adipiodone injection. Adipiodone solution flowed along broken and twisted fiber bundles at dialysate flow rates ranging from 200 to 600 ml/min. In nonsteady state tracer experiments, dialysate was switched from pure water to Adipiodone solution by solenoid-controlled valves after a steady state was reached, and Adipiodone solution (2.4 vol%) was infused into the dialysate compartment for 30 sec at a flow rate of 500 ml/min. Vertical sectional dialysate flow patterns were observed every 2 sec after the start of Adipiodone infusion. Values for dialysate flow velocity at the outer and inner regions of the fiber bundle were 3.5 and 0.6 cm/sec for the CA-170, and 1.4 and 0.7 cm/sec for the HF-200 capillary dialyzer, respectively. This study demonstrates the usefulness of x-ray computed tomography in visually and quantitatively determining dialysate flow patterns in capillary dialyzers.
Pharmacocholangiography
Rofo 1978 Feb;128(2):135-7.PMID:147207DOI:10.1055/s-0029-1230810.
The effect of ouabain and atropine on bile flow and bile iodine concentration in intravenous cholangiography was investigated in 4 cholecystectomized dogs (20 experiments) with complete bile diversion under general anesthesia and compared to the effect of sodium taurocholate. Iodipamide was administered intravenously with an initial priming dose of 50 mg per kg followed by a constant infusion of 2 mg per min per kg. Ouabain in stepwise increasing infusion rates, .0625 to .25 microgram per min per kg, had no significant effect. Atropine infusion rates from 1 to 8 microgram per min kg increased the bile iodine concentration up to 19% but already a 14% increase with a 5% reduction in bile flow was found with the smallest atropine dose. The lowest taurocholate infusion rate resulted in the highest bile iodine concentration and lowest bile flow. It is suggested that atropine premedication and low bile salt plasma levels might improve the opacification of the biliary tree particularly in hepatic dysfunction by reducing selectively specific fractions of the basal bile flow.
Common properties of hepatocellular uptake of cholate, Iodipamide and antamanide, as distinct from the uptake of bromosulfophthalein
Naunyn Schmiedebergs Arch Pharmacol 1983 Mar;322(2):174-9.PMID:6688124DOI:10.1007/BF00512393.
The uptake of Iodipamide and of the cyclopeptide antamanide by isolated hepatocytes was reduced reversibly in the absence of oxygen as recently shown for the transport of cholate. Oligomycin, antimycin A and carbonylcyano-chlorophenylhydrazone (CCCP) completely blocked the uptake of Iodipamide and antamanide whereas the uptake of cholate was only partially decreased. Reduction of ATP in hepatocytes following replacement of glucose by fructose inhibited the uptake of Iodipamide, of antamanide, and also of cholate. In contrast, the penetration of bromosulfophthalein remained unaffected under the above conditions. Arrhenius paralysis yielded high apparent activation energies for the uptake of cholate, Iodipamide, and antamanide being 89, 77 and 55 kJ/mol respectively but only 22 kJ/mol for bromosulfophthalein. Mutual transport inhibition was found for Iodipamide, antamanide and cholate as well as for bromosulfophthalein. Cholate inhibited the uptake of Iodipamide and antamanide competitively. In contrast, bromosulfophthalein inhibited Iodipamide uptake in a mixed order fashion. The results suggest a common uptake mechanism for cholate, Iodipamide and antamanide different from that of bromosulfophthalein.
Biliary excretion of Iodipamide
Gastroenterology 1975 Mar;68(3):554-62.PMID:1112457doi
Conflicting data have been reported concerning the optimum dose and rate of administration of Iodipamide required to obtain maximum radiographic opacification of the biliary tree during intravenous cholangiography. Experiments were performed in dogs to determine the effect of plasma concentration on the excretion and concentration of Iodipamide in the bile and urine during a steady state of infusion and excretion. The data indicate that a hyperbolic relation exists between the plasma concentration and both the biliary concentration and the total biliary excretion. A mathematical expression of these relations is presented. At low plasma concentrations, Iodipamide was not excreted in the urine. However, at high plasma concentrations, urinary excretion increased sharply. It appears that a biliary concentration of Iodipamide sufficient to achieve adequate radiographic visualization of the biliary tree can be obtained without significant renal excretion by constant infusion of Iodipamide at an appropriate rate in dogs. Stepwise increase in the infusion rate until adequate radiographic visualization is obtained may be the best method for performing intravenous cholangiography to obtain visualization with the least amount of Iodipamide in order to minimize toxicity.