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Inarigivir ammonium Sale

(Synonyms: INARIGIVIR铵,ORI-9020 ammonium; SB-9000 ammonium) 目录号 : GC63021

Inarigivir (ORI-9020) ammonium 是一种二核苷酸抗病毒化合物,可显着减少表达乙型肝炎病毒转基因小鼠的 HBV DNA。Inarigivir (ORI-9020) 是 RIG-I 的激动剂,可激活细胞内的先天免疫。

Inarigivir ammonium Chemical Structure

Cas No.:2172788-92-8

规格 价格 库存 购买数量
1 mg
¥4,410.00
现货
5 mg
¥11,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as an RIG-I agonist to activate cellular innate immune responses[1][2].

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[2].

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

[1]. Iyer RP, et al. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20.
[2]. Danni Colledge, et al. The Novel Antiviral Agent Inarigivir Inhibits Both Nucleos(t)ide Analogue and Capsid Assembly Inhibitor Resistant HBV in vitro.

Chemical Properties

Cas No. 2172788-92-8 SDF
别名 INARIGIVIR铵,ORI-9020 ammonium; SB-9000 ammonium
分子式 C20H29N8O10PS 分子量 604.53
溶解度 H2O:100 mg/mL(165.42 mM; Need ultrasonic);DMSO : 100 mg/mL (165.42 mM; Need ultrasonic) 储存条件 4°C, sealed storage, away from moisture
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.6542 mL 8.2709 mL 16.5418 mL
5 mM 0.3308 mL 1.6542 mL 3.3084 mL
10 mM 0.1654 mL 0.8271 mL 1.6542 mL
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