IL36B Human
目录号 : GP20663Interleukin-36 Beta Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Interleukin 36 beta; interleukin 1 family member 8 (eta); Interleukin-1 homolog 2; IL1F8 (Canonical product IL-1F8a); IL-1F8 (FIL1-eta); Interleukin-1 Superfamily e; IL1H2; MGC126880; MGC126882. | ||
| Amino Acid Sequence | MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE | ||
| Solubility | It is recommended to reconstitute the lyophilized IL36B in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized IL36B Human although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL36B should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | Measured by its binding ability in a functional ELISA to bind recombinant human IL-1 Rrp2 Fc Chimera. | ||
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in 1б┴PBS, pH 7.4. | ||
Human IL-36b belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. IL-36 beta is known to be actively secreted. Cells expressing IL-36 beta include resting and activated monocytes and B cells. The receptor for IL-36 beta is a blend of IL-1 Rrp2 and IL-1 RAcP. Recombinant IL-36 beta stimulates processes involving NF-kB and MAPK in an IL-1 Rrp2-dependent manner.
Measured by its binding ability in a functional ELISA to bind recombinant human IL-1 Rrp2 Fc Chimera.
Lyophilized IL36B Human although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL36B should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.