IL 23 Human
目录号 : GP20626Interleukin-23 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by analysis by SDS-PAGE. | Source | HEK. |
| Phycical Appearance | IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Interleukin 23 alpha subunit p19; Interleukin-12 subunit beta p40; SGRF; IL23P19; IL-23-A; interleukin-six; G-CSF related factor; JKA3 induced upon T-cell activation; interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40); NK cell stimulatory factor chain 2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF2; CLMF p40. | ||
| Solubility | It is recommended to reconstitute the lyophilized IL23 in sterile 1xPBS containing 0.1% endotoxin-free recombinant HSA. | ||
| Stability | Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | The activity, as determined by the dose dependent secretion of IL-17 in response to IL-23 using murine splenocytes, the ED50 is 1.9ng/ml. | ||
| Formulation | IL-23 was lyophilized from a 0.1µm filtered solution (1.05mg/ml) containing 1xPBS. | ||
IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of IFN-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
The activity, as determined by the dose dependent secretion of IL-17 in response to IL-23 using murine splenocytes, the ED50 is 1.9ng/ml.
Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.