IER3 Human
目录号 : GP23692Immediate Early Response 3 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | 800x600 immediate early response 3; DIF-2; DIF2; GLY96; IEX-1;IEX-1L; IEX1; PRG1; Protein DIF-2; Immediate early protein GLY96; PACAP-responsive gene 1protein; Differentiation-dependent gene 2 protein; IER3. | ||
| Amino Acid Sequence | 800x600 MGSSHHHHHH SSGLVPRGSH MGSMCHSRSC HPTMTILQAP TPAPSTIPGP RRGSGPEIFT FDPLPEPAAAPAGRPSASRG HRKRSRRVLY PRVVRRQLPV EEPNP. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | 800x600 IER3 protein solution (0.25mg/ml) contains 20mM Tris-HClbuffer, (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. | ||
Immediate Early Response 3 (IER3) functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. IER3 has a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. In addition, IER3 serves as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, IER3 provides pancreatic ductal adenocarcinoma with significant resistance to cell stress, such as starvation.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.