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Iberiotoxin 目录号 GC16254

blocker of the big conductance Ca2+-activated K+ channel

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Sample solution is provided at 25 µL, 10mM.


Quality Control & SDS

View current batch:


Cell experiment [1,2]:

Cell lines

Rat dorsal root ganglion neurons, bladder

Preparation method

Soluble to 0.70 mg/ml in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10-100 nM


Iberiotoxin (IbTX) (10-100 nM) increased the myogenic activity of bladder, but not portal vein. IbTX caused a sustained contracture of aorta. In rat dorsal root ganglion neurons, IbTx (100 nM) reduced whole-cell outward currents in 67% of small and medium size neurons. IbTx significantly prolonged the duration of action potential and increased firing frequency of afferent neurons.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1]. Suarez-Kurtz, G. U. I. L. H. E. R. M. E., Garcia, M. L., & Kaczorowski, G. J. (1991). Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. Journal of Pharmacology and Experimental Therapeutics, 259(1), 439-443.

[2]. Zhang, X. F., Gopalakrishnan, M., & Shieh, C. C. (2003). Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons. Neuroscience, 122(4), 1003-1011.

Chemical Properties

Cas No. 129203-60-7 SDF
别名 N/A
化学名 N/A
Canonical SMILES CC(CC1/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N\C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\2)CCCNC(N)=N)CSSCC2/C(O)=N/C(/C(O)=N/C(C(O)=O)CCC(O)=N)CC3=CC=C(O)C=C3)CCCCN)CCCCN)CCSC)CSSCC(/N=C(O)/C(
分子式 C179H274N50O55S7 分子量 4230.85
溶解度 Soluble in H2O 储存条件 Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。