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HZ-1157 Sale

(Synonyms: 5-叔丁氧基-2,4-二氨基喹唑啉) 目录号 : GC13312

An HCV NS3/4A protease and Dengue virus inhibitor

HZ-1157 Chemical Structure

Cas No.:1009734-33-1

规格 价格 库存 购买数量
5mg
¥720.00
现货
25mg
¥2,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 μmol/L [1].

The NS3 protease of HCV is a prime target for the development of anti-HCV agents because it cleaves the viral polyprotein and liberates NS3, NS4A, NS4B, NS5A, and NS5B, allowing them to function normally in viral RNA replication, and it deactivates many host proteins involved in innate immunity to foster a favorable cellular environment for HCV replication. The NS3 protease is most active when complexed with its cofactor NS4A [1].

In vitro: Huh7.5.1 cell line stably transfected with HCV NS3/4A protease reporter was established to investigate the anti-HCV mechanism of HZ-1157 (0.001~1 μmol/L). The results showed that HZ-1157 exhibited inhibitory effect on the HCV NS3/4A protease with IC50 value of 1.0 μmol/L. HZ-1157 was further tested against an infectious HCV virus (J399EM) which can infect and replicate in Huh7.5.1 cells in vitro. The results showed that HZ-1157 effectively inhibited J399EM virus replication in Huh7.5.1 cells with IC50 value of 0.82 μmol/L [1].

Reference:
[1].  Yu Y, Jing J, Tong X, et al. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease[J]. Acta Pharmacologica Sinica, 2014, 35(8): 1074.

Chemical Properties

Cas No. 1009734-33-1 SDF
别名 5-叔丁氧基-2,4-二氨基喹唑啉
化学名 5-(tert-butoxy)quinazoline-2,4-diamine
Canonical SMILES NC1=NC(N)=NC2=CC=CC(OC(C)(C)C)=C21
分子式 C12H16N4O 分子量 232.28
溶解度 ≥ 11.6mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 4.3051 mL 21.5257 mL 43.0515 mL
5 mM 0.861 mL 4.3051 mL 8.6103 mL
10 mM 0.4305 mL 2.1526 mL 4.3051 mL
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