Home>>Peptides>>GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate)

GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) Sale

(Synonyms: Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate) 目录号 : GC33759

GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) 是一种主要的肠道激素,可从 β 刺激葡萄糖诱导的胰岛素分泌;细胞。

GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) Chemical Structure

Cas No.:1119517-19-9

规格 价格 库存 购买数量
500μg
¥1,071.00
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1mg
¥1,785.00
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5mg
¥5,355.00
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10mg
¥8,479.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) concentrations in the media than those in the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE[1].

Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TO increase the secretion of GLP-1 in a dose-dependent manner. Furthermore, the co-administration of glucose and TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice. When glucose is administered with CPE, active GLP-1 and insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance[1].

[1]. Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36)) amide in C57BL/6J mice. J Nutr Sci. 2015 Mar 3

Chemical Properties

Cas No. 1119517-19-9 SDF
别名 Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate
Canonical SMILES His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
分子式 C149H226N40O45.xC2H4O2 分子量
溶解度 Water : 16.6 mg/mL 储存条件 Store at -20°C
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