Geraniol
(Synonyms: 香叶醇) 目录号 : GC38685
A terpene alcohol with diverse biological activities
Cas No.:106-24-1
Sample solution is provided at 25 µL, 10mM.
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Geraniol is a terpene alcohol found in a variety of plants, including Cannabis, that has diverse biological activities, including insecticide, antioxidant, anti-inflammatory, anticancer, and antimicrobial properties.1,2 Geraniol is an insecticide that induces 100% mortality of C. maculatus, when used at a concentration of 16 ?l in an alimentary substrate.3 It has an LD50 value of 0.714 ?l in C. maculatus but does not produce adverse effects in rats when administered in the diet at 10,000 ppm for 16 weeks.3,2 Topical administration of geraniol (250 ?g) prevents lipid peroxidation, increases glutathione (GSH) levels, and increases the activity of antioxidant enzymes, including catalase, glutathione reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase in a mouse skin model of oxidative stress and inflammation induced by phorbol 12-myristate 13-acetate .4 It also decreases the levels of TNF-α, IL-6, and IL-1β in the same model. Geraniol (100 mg/kg) inhibits HMG-CoA reductase and reduces lipogenesis in hamsters fed an atherogenic diet as a model of hyperlipidemia when administered at a dose of 100 mg/kg.5 It also induces apoptosis in and decreases viability of COLO 205 cancer cells (IC50 = 20 ?M).6 Formulations containing geraniol have been used as fragrance ingredients and as insecticides in agriculture.
1.Elzinga, S., Fischedick, J., Podkolinski, R., et al.Cannabinoids and terpenes as chemotaxonomic markers in CannabisNat. Prod. Chem. Res.3(4)181(2015) 2.Chen, W., and Viljoen, A.M.Geraniol — A review of a commercially important fragrance materialS. Afr. J. Bot.76(4)643-651(2010) 3.Reis, S.L., Mantello, A.G., Macedo, J.M., et al.Typical monoterpenes as insecticides and repellents against stored grain pestsMolecules21(3)258(2016) 4.Khan, A.Q., Khan, R., Qamar, W., et al.Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: Possible role of p38 MAP Kinase and NF-κBExp. Mol. Pathol.94(3)419-429(2013) 5.Jayachandran, M., Chandrasekaran, B., and Namasivayam, N.Effect of geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamstersMol. Cell. Biochem.398(1-2)39-53(2015) 6.Qi, F., Yan, Q., Zheng, Z., et al.Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrestJ. BUON.23(2)346-352(2018)
| Cas No. | 106-24-1 | SDF | |
| 别名 | 香叶醇 | ||
| Canonical SMILES | C/C(C)=C\CC/C(C)=C/CO | ||
| 分子式 | C10H18O | 分子量 | 154.25 |
| 溶解度 | Insoluble in Water; ≥42.7 mg/mL in DMSO; ≥68 mg/mL in EtOH | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.483 mL | 32.4149 mL | 64.8298 mL |
| 5 mM | 1.2966 mL | 6.483 mL | 12.966 mL |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.483 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
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计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
One Hundred Faces of Geraniol
Molecules 2020 Jul 21;25(14):3303.PMID:32708169DOI:10.3390/molecules25143303.
Geraniol is a monoterpenic alcohol with a pleasant rose-like aroma, known as an important ingredient in many essential oils, and is used commercially as a fragrance compound in cosmetic and household products. However, Geraniol has a number of biological activities, such as antioxidant and anti-inflammatory properties. In addition, numerous in vitro and in vivo studies have shown the activity of Geraniol against prostate, bowel, liver, kidney and skin cancer. It can induce apoptosis and increase the expression of proapoptotic proteins. The synergy of this with other drugs may further increase the range of chemotherapeutic agents. The antibacterial activity of this compound was also observed on respiratory pathogens, skin and food-derived strains. This review discusses some of the most important uses of Geraniol.
Pharmacological Properties of Geraniol - A Review
Planta Med 2019 Jan;85(1):48-55.PMID:30308694DOI:10.1055/a-0750-6907.
Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of Geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing Geraniol production through biotechnology processes. The diverse activities of Geraniol suggested that Geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of Geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of Geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of Geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of Geraniol in the context of further development as a drug candidate in clinical application.
Systematic elucidation of the mechanism of Geraniol via network pharmacology
Drug Des Devel Ther 2019 Apr 4;13:1069-1075.PMID:31040644DOI:10.2147/DDDT.S189088.
Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. Methods: In this study, the druggability of Geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of Geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Results: Our findings showed that Geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Conclusion: Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects.
Neuroprotective effect of Geraniol on neurological disorders: a review article
Mol Biol Rep 2022 Nov;49(11):10865-10874.PMID:35900613DOI:10.1007/s11033-022-07755-w.
Background: Neurological disorders are structural, biochemical, and electrical abnormalities that affect the peripheral and central nervous systems. Paralysis, muscle weakness, tremors, spasms, and partial or complete loss of sensation are some symptoms of these disorders. Neurorehabilitation is the main treatment for neurological disorders. Treatments can improve the quality of life of patients. Neuroprotective substances of natural origin are used for the treatments of these disorders. Methods and results: Online databases, such as Google Scholar, PubMed, ScienceDirect, and Scopus were searched to evaluate articles from 1981-2021 using the Mesh words of Geraniol (GER), neurological disorders, epilepsy, spinal cord injury (SCI), Parkinson's diseases (PD), and depression. A total of 87 studies were included in this review. GER with antioxidant, anti-inflammatory, and neuroprotective effects can improve the symptoms and reduce the progression of neurological diseases. GER exhibits neuroprotective effects by binding to GABA and glycine receptors as well as by inhibiting the activation of nuclear factor kappa B (NF-κB) pathway and regulating the expression of nucleotide-binding oligomerization of NLRP3 inflammasome. In this study, the effect of GER was investigated on neurological disorders, such as epilepsy, SCI, PD, and depression. Conclusion: Although the medicinal uses of GER have been reported, more clinical and experimental studies are needed to investigate the effect of using traditional medicine on improving lifethreatening diseases and the quality of life of patients.
Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral
Chem Biol Interact 2022 Aug 1;362:109994.PMID:35661738DOI:10.1016/j.cbi.2022.109994.
In recent years head-to-tail monoterpene Geraniol has been widely explored as a potential anticancer agent. Natural analogs like alcohol nerol, aldehydes geranial, and neral have been investigated. We explored the synergism of these terpenes with clinically and non-clinically used compounds as potential candidates for treating different types of cancer. Promising activity for these compounds has also inspired new analog syntheses. The anticancer potential of these compounds is described in this review.