C-178
(Synonyms: N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺) 目录号 : GC38494
A STING inhibitor
Cas No.:329198-87-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
C-178 is a covalent inhibitor of stimulator of interferon genes (STING).1 It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 ?M) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 ?M.
1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018)
| Cas No. | 329198-87-0 | SDF | |
| 别名 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 | ||
| Canonical SMILES | O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2 | ||
| 分子式 | C17H10N2O5 | 分子量 | 322.27 |
| 溶解度 | DMSO: 41.67 mg/mL (129.30 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.103 mL | 15.5149 mL | 31.0299 mL |
| 5 mM | 0.6206 mL | 3.103 mL | 6.206 mL |
| 10 mM | 0.3103 mL | 1.5515 mL | 3.103 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Cross-linkable bromo-fluorinated poly(arylene ether ketone)s for photonic device applications
Appl Opt 2006 Oct 1;45(28):7480-7.PMID:16983437DOI:10.1364/ao.45.007480.
A series of novel cross-linkable bromo-fluorinated poly(arylene ether ketone)s have been synthesized and used to fabricate photonic devices. The polymers, prepared by polycondensation reactions of decafluorobenzophenone with mixtures of bisphenols in different ratios, exhibit excellent solubility in common organic solvents and can be easily cast into optical-quality thin films by spin coating. The materials are thermally stable with decomposition temperatures (Td, 5% weight loss) over 450 degrees C and have high glass transition temperatures (Tg) in the range of 164 degrees C-178 degrees C. By controlling the bromine content of the polymers, the refractive index can be precisely controlled over a range as wide as 0.07. The material has excellent design flexibility, low optical loss (0.4-0.6 dB/cm at 1550 nm), a low birefringence (2-3 x 10(-3)), and is suitable for use in wavelength sensitive photonic devices based on arrayed waveguide gratings.