Griffonilide
(Synonyms: 格列风内酯) 目录号 : GC38212
Griffonilide 是一种丁烯内酯类化合物，从 Semiaquilegia adoxoides 的根中分离得到，常与紫草甙一起出现。
Cas No.:61371-55-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Griffonilide is a butenolide, isolated from the roots of Semiaquilegia adoxoides, and often occurs alongside lithospermoside[1][2].
[1]. Han QB, et al. Constituents from the roots of Semiaquilegia adoxoides. Fitoterapia. 2001 Jan;72(1):86-8. [2]. Giurleo, Daniel, et al. A phytochemical exploration of Griffonia simplicifolia seeds and leaves.
| Cas No. | 61371-55-9 | SDF | |
| 别名 | 格列风内酯 | ||
| Canonical SMILES | O=C1O[C@@]2([H])C(C=C[C@@H](O)[C@@H]2O)=C1 | ||
| 分子式 | C8H8O4 | 分子量 | 168.15 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.9471 mL | 29.7354 mL | 59.4707 mL |
| 5 mM | 1.1894 mL | 5.9471 mL | 11.8941 mL |
| 10 mM | 0.5947 mL | 2.9735 mL | 5.9471 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Therapeutic and Prophylactic Potential of Morama (Tylosema esculentum): A Review
Phytother Res 2015 Oct;29(10):1423-38.PMID:26206567DOI:10.1002/ptr.5419.
Tylosema esculentum (morama) is a highly valued traditional food and source of medicine for the San and other indigenous populations that inhabit the arid to semi-arid parts of Southern Africa. Morama beans are a rich source of phenolic acids, flavonoids, certain fatty acids, non-essential amino acids, certain phytosterols, tannins and minerals. The plant's tuber contains Griffonilide, behenic acid and starch. Concoctions of extracts from morama bean, tuber and other local plants are frequently used to treat diarrhoea and digestive disorders by the San and other indigenous populations. Information on composition and bioactivity of phytochemical components of T. esculentum suggests that the polyphenol-rich extracts of the bean testae and cotyledons have great potential as sources of chemicals that inhibit infectious microorganisms (viral, bacterial and fungal, including drug-resistant strains), offer protection against certain non-communicable diseases and promote wound healing and gut health. The potential antinutritional properties of a few morama components are also highlighted. More research is necessary to reveal the full prophylactic and therapeutic potential of the plant against diseases of the current century. Research on domestication and conservation of the plant offers new hope for sustainable utilisation of the plant.
Tylosema esculentum extractives and their bioactivity
Bioorg Med Chem 2011 Sep 1;19(17):5225-30.PMID:21813280DOI:10.1016/j.bmc.2011.07.006.
The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded Griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, β-sitosterol 6, behenic acid 7, oleic acid 8, sucrose 9, 2-O-ethyl-α-D-glucopyranoside 10, kaempferol 11 and kaempferol-3-O-β-D-glucopyranoside 12. The structures of the isolates were determined by NMR, HR-TOF EIMS, IR and UV-vis spectroscopy, and by comparison with literature data. The husk EtOAc and n-butanol extracts demonstrated >90% DPPH radical scavenging activity at concentrations of 25, 50 and 250 μg/mL. Furthermore the husk extracts showed higher total phenolic content (233 mg GAE/g). The extractives exhibited minimum inhibitory quantities of 50-100 μg or no activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans. The tuber extracts were inactive against Caco-2 and Hela cell lines, while the husk extracts showed low activity against Caco-2 and Vero cell line with IC(50) values >400 μg/mL. The GC-MS analysis showed the beans and tuber non-polar (n-hexane) extracts major constituents as fatty acids.
Marama bean [Tylosema esculentum (Burch.) A. Schreib.]: an indigenous plant with potential for food, nutrition, and economic sustainability
Food Funct 2021 Mar 21;12(6):2389-2403.PMID:33646215DOI:10.1039/d0fo01937b.
Developing countries need to explore undervalued indigenous plants to fully enhance their food and nutrition security, health, and economic viability. This review explores the nutritional, phytochemical, and economic potential of marama bean (Tylosema esculentum, Fabaceae), a non-nodulating indigenous legume that can be cultivated in and is well-adapted to dry or low moisture conditions. Marama bean is popularly referred to as 'green gold' due to the considerable value derived from its above ground and underground organs. The seeds have nutritional value comparable to legumes such as groundnut and soybean. In addition, the seeds are a rich source of phytochemicals such as phenolic acids, phytosterols, flavonoids, behenic acid and Griffonilide while carbohydrates are abundant in the tubers. Based on the existing literature, marama bean remains poorly explored, mainly anecdotal with limited scientific evidence available to support its nutritional and medicinal uses as well as economic benefits. This has been ascribed to a shortage of clear research goals and limited resources specifically directed to this underutilized indigenous plant. From an economic and commercial perspective, the high phytochemical content suggests the possibility of developing a functional health drink and associated value-added products. However, efficient cultivation protocols for marama bean, especially to ensure the sustainable supply of the plant material, remain crucial. Furthermore, novel approaches, especially the use of molecular techniques that can facilitate rapid selection of desired traits in marama, are recommended. These anticipated improved agronomical traits will enhance the commercial and economical potential of marama and also contribute to rural-urban food-nutrition sustainability globally.
Constituents from the roots of Semiaquilegia adoxoides
Fitoterapia 2001 Jan;72(1):86-8.PMID:11163952DOI:10.1016/s0367-326x(00)00242-2.
The isolation of Griffonilide (1), lithospermoside (2) and magnoflorine (3) from the roots of Semiaquilegia adoxoides is reported.