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β-Boswellic acid Sale

(Synonyms: β-乳香酸) 目录号 : GC38000

A pentacyclic triterpene with diverse bioactivities

β-Boswellic acid Chemical Structure

Cas No.:631-69-6

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产品描述

β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.1 It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 ?M but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid .2 It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 ?M for DNA, RNA, and protein synthesis, respectively.3 In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).4 It also increases calcium mobilization in platelets at concentrations ≥3 ?M and induces platelet aggregation (EC50 = 8 ?M).5

1.Ammon, H.P., Safayhi, H., Mack, T., et al.Mechanism of antiinflammatory actions of curcumine and boswellic acidsJ. Ethnopharmacol.38(2-3)113-119(1993) 2.Safayhi, H., Mack, T., Sabieraj, J., et al.Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenaseJ. Pharmacol. Exp. Ther.261(3)1143-1146(1992) 3.Shao, Y., Ho, C.-T., Chin, C.-K., et al.Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culturePlanta Med.64(4)328-331(1998) 4.Wang, M., Chen, M., Ding, Y., et al.Pretreatment with β-boswellic acid improves blood stasis induced endothelial dysfunction: Role of eNOS activationSci. Rep.5:15357(2015) 5.Siemoneit, U., Tausch, L., Poeckel, D., et al.Defined structure-activity relationships of boswellic acids determine modulation of Ca2+ mobilization and aggregation of human platelets by Boswellia serrata extractsPlanta Med.83(12-13)1020-1027(2017)

Chemical Properties

Cas No. 631-69-6 SDF
别名 β-乳香酸
Canonical SMILES C[C@]12[C@@](CC=C3[C@]2(CC[C@]4(C)[C@@]3([H])[C@H]([C@H](C)CC4)C)C)([H])[C@@]5([C@@]([C@](C)([C@H](O)CC5)C(O)=O)([H])CC1)C
分子式 C30H48O3 分子量 456.7
溶解度 DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml,Ethanol: 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1896 mL 10.9481 mL 21.8962 mL
5 mM 0.4379 mL 2.1896 mL 4.3792 mL
10 mM 0.219 mL 1.0948 mL 2.1896 mL
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