Secretin (28-54), human
(Synonyms: 胰泌素,Human secretin) 目录号 : GC37619
Secretin (28-54), human 是由 27 个氨基酸组成的多肽，作用于分泌素受体 (secretin receptor)。
Cas No.:108153-74-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on secretin receptors. Human secretin receptor[1]
Secretin (28-54), human (Human secretin) binds to secretin receptors on the presynaptic membrane or on the Purkinje cell membrane[1]. Secretin (28-54), human (Human secretin) enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas.Secretin (28-54), human is expressed in the hypothalamus and pituitary gland, and Secretin (28-54), human inhibits adrenocorticotropic hormone (ACTH) release.Secretin (28-54), human selectively depresses the glucocorticoid response to ACTH of dispersed zona fasciculata-reticularis (ZF/R) cells[2]. Secretin (28-54), human (Human secretin) is a 27-amino acid peptide and is the active form of pro-secretin, which is known as a preprohormone and is synthesized as a larger precursor like other regulatory peptides. Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the crypts of LieberkÜhn. Secretin affects the function of a number of organ systems and cell types. Secretin exerts its biological effects through G-protein coupled secretin receptors (SR), which are expressed in the basolateral domain of several cells. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts[3].
[1]. Ng SS, et al. Secretin as a neuropeptide. Mol Neurobiol. 2002 Aug;26(1):97-107. [2]. Nussdorfer GG, et al. Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis. Peptides. 2000 Feb;21(2):309-24. [3]. Afroze S, et al. The physiological roles of secretin and its receptor. Ann Transl Med. 2013 Oct;1(3):29.
| Cas No. | 108153-74-8 | SDF | |
| 别名 | 胰泌素,Human secretin | ||
| 分子式 | C130H220N44O40 | 分子量 | 3039.46 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.329 mL | 1.645 mL | 3.2901 mL |
| 5 mM | 0.0658 mL | 0.329 mL | 0.658 mL |
| 10 mM | 0.0329 mL | 0.1645 mL | 0.329 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。