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Luteolin 7-O-glucuronide Sale

(Synonyms: 木犀草素-7-葡萄糖醛酸苷,Luteolin 7-glucuronide) 目录号 : GC36495

A flavone with diverse biological activities

Luteolin 7-O-glucuronide Chemical Structure

Cas No.:29741-10-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥847.00
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5mg
¥770.00
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10mg
¥1,260.00
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25mg
¥2,730.00
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产品描述

Luteolin 7-O-glucuronide is a flavonoid that has been found in S. chloroleuca and A. pilosa, and has diverse biological activities, including antioxidant, enzyme inhibitory, and anti-inflammatory properties.1,2,3 It scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM).1 Luteolin 7-O-Glucuronide inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively).3 It also inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens by 91.8% when used at a concentration of 5 μg/ml.1 Luteolin 7-O-glucuronide inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner.2

1.Kim, S.B., Hwang, S.H., Suh, H.-W., et al.Phytochemical analysis of Agrimonia pilosa Ledeb, its antioxidant activity and aldose reductase inhibitory potentialInt. J. Mol. Sci.18(2)379(2017) 2.Cho, Y.-C., Park, J., and Cho, S.Anti-inflammatory and anti-oxidative effects of luteolin-7-O-glucuronide in LPS-stimulated murine macrophages through TAK1 inhibition and Nrf2 activationInt. J. Mol. Sci.21(6)2007(2020) 3.Asghari, B., Salehi, P., Sonboli, A., et al.Flavonoids from Salvia chloroleuca with α-amylsae and α-glucosidase inhibitory effectIran. J. Pharm. Res.14(2)609-615(2015)

Chemical Properties

Cas No. 29741-10-4 SDF
别名 木犀草素-7-葡萄糖醛酸苷,Luteolin 7-glucuronide
Canonical SMILES O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C(O)=C4)OC3=C2)=O
分子式 C21H18O12 分子量 462.36
溶解度 DMSO: 130 mg/mL (281.17 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1628 mL 10.8141 mL 21.6282 mL
5 mM 0.4326 mL 2.1628 mL 4.3256 mL
10 mM 0.2163 mL 1.0814 mL 2.1628 mL
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Research Update

Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Int J Environ Res Public Health 2019 Jul 23;16(14):2615.PMID:31340457DOI:10.3390/ijerph16142615.

Enhalus acoroides (E. acoroides) is one of the most common species in seagrass meadows. Based on the application of allelochemicals from aquatic plants to inhibit harmful algal blooms (HABs), we used E. acoroides aqueous extract against harmful algae species Phaeocystis globosa (P. globosa). The results showed that E. acoroides aqueous extract could significantly inhibited the growth of P. globosa, decrease the chlorophyll-a content and photosynthetic efficiency (Fv/Fm) values of P. globosa, followed by vacuolization, plasmolysis, and the destruction of organelles. Twelve types of major chemical constituents were identified in E. acoroides aqueous extracts by ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS), including six flavonoids, two homocyclic peptides, two long-chain aliphatic amides, one tannin, and one nitrogen heterocyclic compound. Flavonoids were the characteristic chemical constituents of E. acoroides aqueous extract. Furthermore, the antialgal activity of luteolin-7-O-glucuronide (68.125 μg/mL in 8 g/L E. acoroides aqueous extract) was assessed. The EC50-96 h value was 34.29 μg/mL. In conclusion, the results revealed that Luteolin 7-O-glucuronide was one of the antialgal compounds of E. acoroides aqueous extract, with potential application as novel algaecide.

Phytochemical study of polyphenols in Perilla Frutescens as an antioxidant

Avicenna J Phytomed 2012 Fall;2(4):169-78.PMID:25050247doi

Perilla frutescens is an annual herb of the mint family native to East Asia. Polyphenols present in perilla have various structural varieties with large diversity of biological activities. It is direct influence the quality of perilla plant and their potential functions. Some of these products have been studied and proven to be effective source of phenolic antioxidants. The aqueous extract contains phenolic compounds such as phenolic acids, cinnamic acid derivatives, flavonoids, and lignans. Gallic acid, hydroxytyrosol (3,4-DHPEA), cinnamic acid derivatives (coumaroyl tartaric acid, caffeic acid and rosmarinic acid), flavonoids, scutellarein 7-O-diglucuronide, luteolin 7-O-diglucuronide, apigenin 7-O-diglucuronide, Luteolin 7-O-glucuronide, and scutellarein 7-O-glucuronide), and anthocyanins (mainly cis-shisonin, shisonin, malonylshisonin and cyanidin 3-O-(E)-caffeoylglucoside-5-O-malonylglucoside) are present.

Antioxidant activities of polyphenols extracted from Perilla frutescens varieties

Molecules 2008 Dec 31;14(1):133-40.PMID:19127243DOI:10.3390/molecules14010133.

Various cultivars of Perilla frutescens (L.) (var. crispa and var. frutescens) Britt. were harvested in China and Japan. They were easily differentiated on the basis of their foliage color, that varied from red to green. Water extracts of dried plants were investigated for their antioxidant activity (AA) and their polyphenolic compounds compared. Among them, cinnamic acid derivatives (coumaroyl tartaric acid, caffeic acid and rosmarinic acid), flavonoids (apigenin 7-O-caffeoylglucoside, scutellarein 7-O-diglucuronide, luteolin 7-O-diglucuronide, apigenin 7-O-diglucuronide, Luteolin 7-O-glucuronide, and scutellarein 7-O-glucuronide) and anthocyanins (mainly cis-shisonin, shisonin, malonylshisonin and cyanidin 3-O-(E)-caffeoylglucoside-5-O-malonylglucoside) were quantified. AA assays are based on the inhibition of the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The DPPH radical scavenging activity was calculated as Trolox [(+/-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid] equivalent antioxidant capacity (TEAC). The mean amount of total phenolics of the water extracts (4-29 micromol/100 mL) and the TEAC value calculated (23-167 micromol TE/100 mL) confirmed the high antioxidant activity of these leaf water extracts. These results were highly correlated within some o-dihydroxylated polyphenolic compounds and AA.

Isolation of some luteolin derivatives from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potencies

Food Chem 2012 Nov 15;135(2):764-9.PMID:22868156DOI:10.1016/j.foodchem.2012.04.137.

This study was designed to evaluate the mutagenic and antimutagenic activities of luteolin derivatives (luteolin 7-O-glucoside, luteolin 7-O-rutinoside and Luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds. subsp. longifolia by using Ames Salmonella test (TA 1535 and TA1537 strains). In the antimutagenicity assays, luteolin 7-O-glucoside, luteolin 7-O-rutinoside and Luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and TA1535 strains. The highest inhibition rates for luteolin 7-O-glucoside, luteolin 7-O-rutinoside and Luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.77%, respectively. Similarly, in the antimutagenicity assays performed with the TA1535 strain, the inhibition rates for luteolin 7-O-glucoside and luteolin 7-O-rutinoside were 23.86% and 23.76% respectively. Our findings showed that the antimutagenic properties of luteolin derivatives on TA1537 and TA1535 strains have been found to be structure dependent. The clarification of differences in antimutagenic potency of these luteolin derivatives based on their structures has been demonstrated in this study.

A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews

Molecules 2010 Apr 12;15(4):2593-9.PMID:20428066DOI:10.3390/molecules15042593.

Sonchus erzincanicus (Asteraceae) is an endemic species in Turkey, where six Sonchus species grow. In this study, a phytochemical study was performed on the aerial parts of the plant. The study describes the isolation and structure elucidation of five flavonoids and two a-ionone glycosides from S. erzincanicus. The compounds were isolated using several and repeated chromatographic techniques from ethyl acetate and aqueous phases that were partitioned from a methanol extract obtained from the plant. 5,7,3',4'-Tetrahydroxy-3-methoxyflavone (1) and quercetin 3-O-beta-D-glucoside (2) were isolated from the ethyl acetate phase, while corchoionoside C 6'-O-sulfate (3), corchoionoside C (4), Luteolin 7-O-glucuronide (5) and luteolin 7-O-beta-D-glucoside (6), apigenin 7-O-glucuronide (7) were isolated from the aqueous phase. Corchoionoside C 6'-O-sulfate (3), isolated for the first time from a natural source, was a new compound. The structures of the compounds were elucidated by means of 1H-NMR, 13C-NMR, 2D-NMR (COSY, HMQC, HMBC) and ESI-MS.