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Fluvastatin D6 sodium Sale

(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6)) 目录号 : GC36061

An internal standard for the quantification of fluvastatin

Fluvastatin D6 sodium Chemical Structure

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1mg
¥2,655.00
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5mg
¥9,180.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Fluvastatin-d6 is intended for use as an internal standard for the quantification of fluvastatin by GC- or LC-MS. Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme).1,2 It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).3 Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc- cystine-glutamate antiporter levels in human umbilical vein endothelial cells (HUVECs).4 In vivo, fluvastatin (2 mg/kg per day) decreases serum cholesterol, triglyceride, and phospholipid levels, the formation of thiobarbituric acid-reactive substances (TBARS), and vascular angiotensin-converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.5 It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.6 Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.

1.Istvan, E.S., and Deisenhofer, J.Structural mechanism for statin inhibition of HMG-CoA reductaseScience292(5519)1160-1164(2001) 2.Corsini, A., Maggi, F.M., and Catapano, A.L.Pharmacology of competitive inhibitors of HMG-CoA reductasePharmacol. Res.31(1)9-27(1995) 3.Transon, C., Leemann, T., and Dayer, P.In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitorsEur. J. Clin. Pharmacol.50(3)209-215(1996) 4.Li, Q., Liu, C., Deng, L., et al.Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent mannerExp. Ther. Med.22(5)1275(2021) 5.Mitani, H., Bandoh, T., Ishikawa, J., et al.Inhibitory effects of fluvastatin, a new HMG-CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbitsBr. J. Pharmacol.119(6)1269-1275(1996) 6.Hayashidani, S., Tsutsui, H., Shiomi, T., et al.Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarctionCirculation105(7)868-873(2002)

Chemical Properties

Cas No. SDF
别名 氟伐他汀钠D6; XU 62-320 (D6)
Canonical SMILES O=C([O-])C[C@H](O)C[C@H](O)/C=C/C(N1C(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3.[Na+]
分子式 C24H19D6FNNaO4 分子量 439.48
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2754 mL 11.3771 mL 22.7542 mL
5 mM 0.4551 mL 2.2754 mL 4.5508 mL
10 mM 0.2275 mL 1.1377 mL 2.2754 mL
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