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Cetirizine D8 dihydrochloride Sale

(Synonyms: 盐酸西替利嗪 D8) 目录号 : GC35656

An internal standard for the quantification of cetirizine,(R)-cetirizine, and (S)-cetirizine

Cetirizine D8 dihydrochloride Chemical Structure

Cas No.:2070015-04-0

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1mg
¥1,620.00
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5mg
¥5,850.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Cetirizine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cetirizine , (R)-cetirizine , and (S)-cetirizine by GC- or LC-MS. Cetirizine is a bioactive carboxylated metabolite of hydroxyzine that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM).1,2 As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit.3 Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, (R)-cetirizine and (S)-cetirizine, with pharmacological activity residing primarily in the (R) isomer.2 Cetirizine inhibits eosinophil chemotaxis and leukotriene B4 release independent from H1 antagonism.4 It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED50 = 100 μg/kg, p.o.).5 Formulations containing cetirizine have been used in the treatment of allergic rhinitis and chronic urticaria.

1.Thurmond, R.L., Gelfand, E.W., and Dunford, P.J.The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistaminesNat. Rev. Drug Discov.7(1)41-53(2008) 2.Zhang, L., Cheng, L., and Hong, J.The clinical use of cetirizine in the treatment of allergic rhinitisPharmacology92(1-2)14-25(2013) 3.Tillement, J.P.The advantages for an H1 antihistamine of a low volume of distributionAllergy55(suppl 60)17-21(2000) 4.K?ller, M., Hilger, R.A., Rihoux, J.P., et al.Cetirizine exerts anti-inflammatory effects on human neutrophilsInt. Arch. Allergy. Immunol.110(1)52-56(1996) 5.Llupià, J., Gras, J., and Llenas, J.Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical modelsArzneimittelforschung53(2)93-97(2003)

Chemical Properties

Cas No. 2070015-04-0 SDF
别名 盐酸西替利嗪 D8
Canonical SMILES ClC1=CC=C(C(N2C([2H])([2H])C([2H])([2H])N(CCOCC(O)=O)C([2H])([2H])C2([2H])[2H])C3=CC=CC=C3)C=C1.Cl.Cl
分子式 C21H19D8Cl3N2O3 分子量 469.86
溶解度 Methanol: slightly soluble,Water: slightly soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1283 mL 10.6415 mL 21.2829 mL
5 mM 0.4257 mL 2.1283 mL 4.2566 mL
10 mM 0.2128 mL 1.0641 mL 2.1283 mL
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