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Ceftibuten dihydrate Sale

(Synonyms: 头孢布烯二水合物; Sch-39720 dihydrate) 目录号 : GC35647

A broad-spectrum cephalosporin antibiotic

Ceftibuten dihydrate Chemical Structure

Cas No.:118081-34-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥594.00
现货
10mg
¥540.00
现货
50mg
¥1,530.00
现货
100mg
¥2,070.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Ceftibuten is an orally bioavailable broad-spectrum cephalosporin antibiotic that inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively).1,2 Ceftibuten is also active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively). In vivo, ceftibuten reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection by 50% when administered subcutaneously at doses of 0.125, 2, 1,024, and >512 mg/kg, respectively.3 Formulations containing ceftibuten have been used in the treatment of bacterial infections including bronchitis, pneumonia, and enteritis.

1.Bauernfeind, A.Ceftibuten and bactericidal kinetics. Comparative in vitro activity against Enterobacteriaceae producing extended spectrum β-lactamasesDiagn. Microbiol. Infect. Dis.14(1)89-92(1991) 2.Jones, R.N., and Barry, A.L.Antimicrobial activity, spectrum, and recommendations for disk diffusion susceptibility testing of ceftibuten (7432-S; SCH 39720), a new orally administered cephalosporinAntimicrob. Agents Chemother.32(10)1576-1582(1988) 3.Onyeji, C.O., Nicolau, D.P., Nightingale, C.H., et al.Optimal times above MICs of ceftibuten and cefaclor in experimental intra-abdominal infectionsAntimicrob. Agents Chemother.38(5)1112-1117(1994)

Chemical Properties

Cas No. 118081-34-8 SDF
别名 头孢布烯二水合物; Sch-39720 dihydrate
Canonical SMILES O=C(C(N12)=CCS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=C\CC(O)=O)=O)C1=O)O.O.O
分子式 C15H18N4O8S2 分子量 446.46
溶解度 DMSO: 100 mg/mL (223.98 mM); Water: < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2398 mL 11.1992 mL 22.3984 mL
5 mM 0.448 mL 2.2398 mL 4.4797 mL
10 mM 0.224 mL 1.1199 mL 2.2398 mL
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