Bithionol sulfoxide
(Synonyms: 硫双二氯酚亚砜) 目录号 : GC35526
Bithionol sulfoxide(Bitin-S)是一抗寄生虫化合物，被研究显示具有抗癌活性。
Cas No.:844-26-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].
[1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61. [2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62.
| Cas No. | 844-26-8 | SDF | |
| 别名 | 硫双二氯酚亚砜 | ||
| Canonical SMILES | O=S(C1=CC(Cl)=CC(Cl)=C1O)C2=CC(Cl)=CC(Cl)=C2O | ||
| 分子式 | C12H6Cl4O3S | 分子量 | 372.05 |
| 溶解度 | DMSO: ≥ 250 mg/mL (671.95 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6878 mL | 13.4391 mL | 26.8781 mL |
| 5 mM | 0.5376 mL | 2.6878 mL | 5.3756 mL |
| 10 mM | 0.2688 mL | 1.3439 mL | 2.6878 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Liquid chromatographic determination of depletion of Bithionol sulfoxide and its two major metabolites in bovine milk
J Assoc Off Anal Chem 1987 Sep-Oct;70(5):810-2.PMID:3680115doi
A liquid chromatographic method is described for determining Bithionol sulfoxide and its metabolites, bithionol and bithionol sulfone, in milk. Samples are treated with HCl to precipitate proteins and to permit extraction of Bithionol sulfoxide in nonionized form. Tetrahydrofuran is added to the organic phase to facilitate extraction in diethyl ether; the dried residue is dissolved in chloroform, hexane, and sodium hydroxide and subjected to LC analysis. Residues of Bithionol sulfoxide and its 2 metabolites were determined in milk of lactating cows. Holstein-Friesian dairy cows were administered a single oral dose of Bithionol sulfoxide (50 mg/kg). Milk samples were analyzed with a reliable detection level of 0.025 microgram/mL for each compound. Residues of Bithionol sulfoxide and bithionol were detected during 30 and 16 milkings, respectively; bithionol sulfone was never present at detectable levels.
Mutagenicity of Bithionol sulfoxide and its metabolites in the salmonella/mammalian microsome test
Mutat Res 1987 May;188(1):53-5.PMID:3553922DOI:10.1016/0165-1218(87)90114-5.
The mutagenic effects of Bithionol sulfoxide and its two major metabolites, bithionol and bithionol sulfone, on 4 Salmonella typhimurium strains (TA97, TA98, TA100 and TA102) were investigated. Bithionol sulfoxide was found to be mutagenic to TA98 and TA100. However, mutagenicity was abolished in the presence of rat-liver S9 fractions.
[Autoradiographic study of the distribution of 14C Bithionol sulfoxide in mice (author's transl)]
Toxicol Eur Res 1982 Mar;4(2):101-5.PMID:7112565doi
The distribution of a single oral dose of 14C Bithionol sulfoxide in mice was determined by whole body autoradiography. The Bithionol sulfoxide was found in the whole organism mainly in richly vascularized organs, liver, kidney, lung. It did not pass through the blood-brain barrier and did not accumulate in any particular organ but persisted in the blood. Observations were performed in 18-day pregnant mice in order to investigate an eventual placental transfer. Six hours after the administration, radioactivity was detected in blood and fetal vascularized tissues.
[The prevention and therapy of fascioloidiasis using Bithionol sulfoxide]
Vet Med (Praha) 1980 Sep;25(9):557-63.PMID:6777958doi
The elimination of the sources of invasion, i. e. hay and forage coming from the infested biotopes, combined with the administration of bithionol sulphoxide, resulted in a reduction of the invasion of cattle by Fascioloides magna from 21.1 to 3.2% within two years. The Czechoslovak-produced bithionol sulphoxide, administered at a rate of 40 to 50 mg per kg body weight as medicated feed, showed 100% effectiveness. At doses higher than 30 mg per kg body weight, the protective period should be prolonged to three or four weeks.
[A Study On The Chemotherapy In Clonorchiasis: Report 1. An Experimental Study On Chemotherapy With Dithiazanine Iodide And Bithionol sulfoxide In Clonorchiasis]
Kisaengchunghak Chapchi 1965 Jun;3(1):19-30.PMID:12913591DOI:10.3347/kjp.1965.3.1.19.
Authors carried out experimental study on chemotherapy with oral administration of Dithiazanine iodide (D.I.) and Bithionol sulfoxide(B.S.) in rabbit clonorchiasis. And the following result was obtained. 1)In change of the E.P.G (eggs per gram feces) by D.I. administration, it was rather increased in early stage of the administration than prior to administration, and thereafter decreased gradually. 2)In the change of the C.S. worm body by D.I. administration, there was not only prominent change of supporting tissue but also the change of reproductive organ was found. 3)In considering the wormicidal effect of D.I. from detecting rate of survival worms, the effect was slight in group of 100 mg(80 mg/kg) per day dosage, but the effects were very excellent and almost complete by proper times of administration in groups of 200 mg (130 mg/kg) per day or higher dosage. 4)But the side effect and intoxication sign of D.I. were appearent in groups of 200 mg or higher dosage. 5)By B.S. administration, E.P.G. was decreased gradually. 6)In changes of the C.S. worm body by B.S. administration, prominent inhibitory chnnge was seen in egg formation ability. 7)Slight wormicidal effect of B.S. was observed in groups of 140 mg (100 mg/kg) per day or higher dosage. 8)Side effect and intoxication sign of B.S. were found little in groups of 140 mg or lesser dosage.