Home>>Signaling Pathways>> GPCR/G protein>> Leukotriene Receptor>>5-O-Demethylnobiletin

5-O-Demethylnobiletin Sale

(Synonyms: 去甲基川陈皮素,5-Demethylnobiletin) 目录号 : GC35168

A flavonoid with diverse biological activities

5-O-Demethylnobiletin Chemical Structure

Cas No.:2174-59-6

规格 价格 库存 购买数量
1mg 待询 待询
5mg
¥1,422.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

5-O-Demethylnobiletin is a flavonoid that has been found in S. tragoriganum and has diverse biological activities.1,2,3,4 It induces neurite outgrowth and the expression of the genes encoding the neuronal differentiation and synapse formation markers growth-associated protein 43 (GAP43) and synaptophysin in PC12 cells when used at concentrations ranging from 10 to 20 ?M.1 5-O-Demethylnobiletin (2.5-20 ?M) reduces triglyceride levels in 3T3-L1 preadipocytes and decreases body weight, intra-abdominal fat, plasma and liver triglyceride levels, and plasma cholesterol levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 25 mg/kg.2 It reduces hepatic fibrosis and malondialdehyde (MDA) levels in a mouse model of carbon tetrachloride-induced liver injury.3 5-O-Demethylnobiletin also reduces ear edema, inflammatory cell infiltration, and papillar fibrosis in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate .4

1.Chiu, S.-P., Wu, M.-J., Chen, P.-Y., et al.Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cellsJ. Agric. Food Chem61(39)9453-9463(2013) 2.Tung, Y.-C., Li, S., Huang, Q., et al.5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone suppress lipid accumulation by activating the LKB1-AMPK pathway in 3T3-L1 preadipocytes and high fat diet-fed C57BL/6 miceJ. Agric. Food Chem64(16)3196-3205(2016) 3.Chang, S.N., Kim, S.H., Dey, D.K., et al.5-O-Demethylnobiletin alleviates CCL4-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy inductionInt. J. Mol. Sci.22(3)1083(2021) 4.Bas, E., Recio, M.C., Giner, R.M., et al.Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganumPlanta Med.72(2)136-142(2006)

Chemical Properties

Cas No. 2174-59-6 SDF
别名 去甲基川陈皮素,5-Demethylnobiletin
Canonical SMILES O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
分子式 C20H20O8 分子量 388.37
溶解度 Soluble in DMSO 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.5749 mL 12.8743 mL 25.7486 mL
5 mM 0.515 mL 2.5749 mL 5.1497 mL
10 mM 0.2575 mL 1.2874 mL 2.5749 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置