Home>>Signaling Pathways>> Cancer Biology>>Enobosarm-d4

Enobosarm-d4 Sale

(Synonyms: (2S)-3-(4-氰基苯氧基-2,3,5,6-D4)-N-[4-氰基-3-(三氟甲基)苯基]-2-羟基-2-甲基丙酰胺) 目录号 : GC49648

An internal standard for the quantification of enobosarm

Enobosarm-d4 Chemical Structure

Cas No.:1202044-20-9

规格 价格 库存 购买数量
500 µg
¥1,697.00
现货
1 mg
¥3,236.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

Enobosarm-d4 is intended for use as an internal standard for the quantification of enobosarm by GC- or LC-MS. Enobosarm is a non-steroidal selective androgen receptor modulator (SARM; Ki = 0.0038 µM in a radioligand binding assay).1 It is a partial agonist of the androgen receptor (IC50 = 0.0364 µM in a transactivation assay) and inhibits the proliferation of 22Rv1, DU145, LNCaP, and VCaP prostate cancer cells (IC50s = 24.77, 44.55, 20.9, and 24.47 µM, respectively).2 Enobosarm (0.001 and 0.01 µM) inhibits lipogenesis in isolated rat adipocytes.3 It increases the weights of the prostate gland and seminal vesicles, markers of androgenic activity, and the levator ani muscle, a marker of anabolic activity, in castrated rats (ED50s = 0.12, 0.39, and 0.03 mg/day, respectively).1

1.Kim, J., Wu, D., Hwang, D.J., et al.The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulatorsJ. Pharmacol. Exp. Ther.315(1)230-239(2005) 2.Bassetto, M., Ferla, S., Pertusati, F., et al.Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancerEur. J. Med. Chem.118230-243(2016) 3.Leciejewska, N., Pruszynska-Oszmalek, E., Bien, J., et al.Effect of ostarine (enobosarm/GTX024), a selective androgen receptor modulator, on adipocyte metabolism in Wistar ratsJ. Physiol. Pharmacol.70(4)525-533(2019)

Chemical Properties

Cas No. 1202044-20-9 SDF Download SDF
别名 (2S)-3-(4-氰基苯氧基-2,3,5,6-D4)-N-[4-氰基-3-(三氟甲基)苯基]-2-羟基-2-甲基丙酰胺
Canonical SMILES FC(F)(C1=C(C=CC(NC([C@@](C)(O)COC2=C([2H])C([2H])=C(C([2H])=C2[2H])C#N)=O)=C1)C#N)F
分子式 C19H10D4F3N3O3 分子量 393.4
溶解度 DMF: soluble,DMSO: soluble,Methanol: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.5419 mL 12.7097 mL 25.4194 mL
5 mM 0.5084 mL 2.5419 mL 5.0839 mL
10 mM 0.2542 mL 1.271 mL 2.5419 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置