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Emodepside (Bay 44-4400) Sale

(Synonyms: 艾默德斯,Bay 44-4400) 目录号 : GC33940

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.

Emodepside (Bay 44-4400) Chemical Structure

Cas No.:155030-63-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥2,439.00
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5mg
¥1,260.00
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10mg
¥1,980.00
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50mg
¥6,300.00
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100mg
¥10,800.00
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产品描述

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.

[1] A Harder, et al. Parasitol Res. 2005 Oct;97 Suppl 1:S1-S10. [2] S K Buxton, et al. Br J Pharmacol. 2011 Sep;164(2b):453-70.

Chemical Properties

Cas No. 155030-63-0 SDF
别名 艾默德斯,Bay 44-4400
Canonical SMILES O=C(N([C@H](C(O[C@](C(N([C@H](C(O[C@H](CC1=CC=C(N2CCOCC2)C=C1)C(N(C)[C@H](CC(C)C)C(O[C@H](C)C(N(C)[C@@H](CC(C)C)C3=O)=O)=O)=O)=O)CC(C)C)C)=O)([H])C)=O)CC(C)C)C)[C@H](O3)CC4=CC=C(N5CCOCC5)C=C4
分子式 C60H90N6O14 分子量 1119.39
溶解度 DMSO : ≥ 31 mg/mL (27.69 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 0.8933 mL 4.4667 mL 8.9334 mL
5 mM 0.1787 mL 0.8933 mL 1.7867 mL
10 mM 0.0893 mL 0.4467 mL 0.8933 mL
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Research Update

Activity of the cyclic depsipeptide Emodepside (Bay 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival

Parasitol Res 2001 Nov;87(11):924-8.PMID:11728017DOI:10.1007/s004360100479

The present investigations deal with the activity of the cyclic depsipeptide Emodepside (Bay 44-4400) against larval and adult stages of three rodent nematodes. While emodepside acts strongly against the adult stages of the rat nematodes Nippostrongylus brasiliensis and Strongyloides ratti, as well as against the mouse nematode Heligmosomoides polygyrus, its actions against the larval stages of these nematodes vary according to the species. Thus, emodepside is highly effective against the lung and intestine larval stages of N. brasiliensis and S. ratti. By contrast. the larval stages of H. polygyrus in the intestine are only partly affected by higher emodepside dosages.