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(E/Z)-ZINC09659342 Sale

目录号 : GC64657

(E/Z)-ZINC09659342 是 Lbc-RhoA 相互作用的抑制剂。

(E/Z)-ZINC09659342 Chemical Structure

Cas No.:591726-26-0

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5 mg
¥3,420.00
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10 mg
¥5,400.00
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25 mg
¥10,350.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction[1].

[1]. Francesca FANELLI, et al. Compounds and composition for use in the inhibition of the lbc-rhoa interaction, in particular for the treatment of cancer. WO2015028929A1.

Chemical Properties

Cas No. 591726-26-0 SDF Download SDF
分子式 C23H15F3N2O4 分子量 440.37
溶解度 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2708 mL 11.3541 mL 22.7082 mL
5 mM 0.4542 mL 2.2708 mL 4.5416 mL
10 mM 0.2271 mL 1.1354 mL 2.2708 mL
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Research Update

Deracemization through photochemical E/ Z isomerization of enamines

Science 2022 Feb 25;375(6583):869-874.PMID:35201874DOI:10.1126/science.abl4922.

Catalytic deracemization of α-branched aldehydes is a direct strategy to construct enantiopure α-tertiary carbonyls, which are essential to pharmaceutical applications. Here, we report a photochemical E/Z isomerization strategy for the deracemization of α-branched aldehydes by using simple aminocatalysts and readily available photosensitizers. A variety of racemic α-branched aldehydes could be directly transformed into either enantiomer with high selectivity. Rapid photodynamic E/Z isomerization and highly stereospecific iminium/enamine tautomerization are two key factors that underlie the enantioenrichment. This study presents a distinctive photochemical E/Z isomerization strategy for externally tuning enamine catalysis.

E/ Z photoisomerization pathway in pristine and fluorinated di(3-furyl)ethenes

Phys Chem Chem Phys 2022 Oct 5;24(38):23749-23757.PMID:36156663DOI:10.1039/d2cp02563a.

We report an XMCQDPT2 study of the E/Z photoisomerization in a series of fluorinated di(3-furyl)ethenes (3DFEs). Upon excitation, pristine and low-fluorinated 3DFE show conventional behavior of many diarylethenes: unhindered twisting motion toward the pyramidalized zwitterionic state where relaxation to the ground state occurs. However, deep fluorination of 3DFEs can hamper E-to-Z isomerization by giving rise to an alternative excited-state relaxation pathway: an out-of-plane motion of a ring fluorine atom. Importantly, the case of fluorinated 3DFEs reveals serious deficiencies of the popular TDDFT approach. With some commonly used exchange-correlation functionals, the alternative relaxation pathway is not reproduced and, moreover, an irrelevant ring rotation coordinate is predicted instead. Nevertheless, TDDFT remains qualitatively adequate for the E-to-Z twisting coordinate taken alone.

Configuration-Controllable E/Z Isomers Based on Tetraphenylethene: Synthesis, Characterization, and Applications

ACS Appl Mater Interfaces 2019 Feb 13;11(6):6302-6314.PMID:30663301DOI:10.1021/acsami.8b19672.

Configuration-controllable E/Z isomers based on tetraphenylethene were prepared with a facile and effective method. First, compounds 1 and 2, configuration-controllable precursors of E/Z isomers, were synthesized. Then, pure E/Z isomers were obtained via Suzuki reaction, avoiding the difficulties of separation. The conformational changes of E/Z isomers can occur through photoactivation. Importantly, red-shifts of 66 nm from 6 (E-) to 3 (Z-) and 58 nm from 7 (E-) to 4 (Z-) were observed remarkably on the photoluminescence (PL) emission spectra. The Z isomer showed a longer fluorescence lifetime compared with the E isomer. The Z isomers 3 and 4 exhibited piezofluorochromism under grinding, whereas the E isomers 6 and 7 showed no such behaviors. The E isomer has better thermal stability than the Z isomer. Lastly, graphene-like molecules were synthesized with the FeCl3/CH3NO2 system. The E and Z isomers after oxidation showed negligible differences in the PL emission spectra because the effective conjugated lengths of oxidized E and Z isomers were both extended. Furthermore, the fabricated field-effect transistors showed nice performance with mobilities of 0.92 and 1.14 cm-2 V-1 s-1 at low operating voltages, respectively.

Probing E/Z Isomerism Using Pillar[4]pyridinium/Gold Nanoparticle Ensembles and Their Photoresponsive Behavior

Langmuir 2022 Apr 26;38(16):4942-4947.PMID:35426683DOI:10.1021/acs.langmuir.2c00342.

Despite the fundamental importance and broad applicability of E/Z dicarboxylic acids, their discrimination remains challenging and greatly unexplored. Herein, we present a general approach for the recognition of E/Z diacids using supramolecular interactions coupled with plasmonic response. The method allows detecting both single isomers and their light-induced interconversion, which ultimately entails multiple reversible nanoparticle aggregations. Such a molecular recognition-coupled responsive nanoscale self-assembly resembles natural mechanisms and can be a versatile means of building artificial complexity.

Application of E/Z-Isomerization Technology for Enhancing Processing Efficiency, Health-Promoting Effects, and Usability of Carotenoids: A Review and Future Perspectives

J Oleo Sci 2022 Feb 3;71(2):151-165.PMID:35034944DOI:10.5650/jos.ess21338.

Carotenoids are naturally occurring pigments whose presence in the diet is beneficial to human health. Moreover, they have a wide range of applications in the food, cosmetic, and animal feed industries. As carotenoids contain multiple conjugated double bonds in the molecule, a large number of geometric (E/Z, trans/cis) isomers are theoretically possible. In general, (all-E)-carotenoids are the most predominant geometric isomer in nature, and they have high crystallinity and low solubility in various mediums, resulting in their low processing efficiency and bioavailability. Technological developments for improving the processing efficiency and bioavailability of carotenoids utilizing the Z-isomerization have recently been gaining traction. Namely, Z-isomerization of carotenoids induces a significant change in their physicochemical properties (e.g., solubility and crystallinity), leading to improved processing efficiency and bioavailability as well as several biological activities. For the practical use of isomerization technology for carotenoids, the development of efficient isomerization methods and an acute understanding of the changes in biological activity are required. This review highlights the recent advancements in various conventional and unconventional methods for carotenoid isomerization, such as thermal treatment, light irradiation, microwave irradiation, and catalytic treatment, as well as environment-friendly isomerization methods. Current progress in the improvement of processing efficiency and biological activity utilizing isomerization technology and an application development of carotenoid Z-isomers for the feed industry are also described. In addition, future research challenges in the context of carotenoid isomerization have been elaborated upon.