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DMABA-d4 NHS ester Sale

(Synonyms: 4(dimethylamino) Benzoic Acidd4, DMABA Nhydroxysuccinimide esterd4, NSuccinimidyl 4(dimethylamino)benzoated4) 目录号 : GC47248

An internal standard for the quantification of DMABA NHS ester

DMABA-d4 NHS ester Chemical Structure

Cas No.:1175002-03-5

规格 价格 库存 购买数量
1 mg
¥1,490.00
现货
5 mg
¥6,716.00
现货
10 mg
¥11,923.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

DMABA-d4 NHS ester is intended for use in combination with DMABA NHS ester as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d4 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.1 Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.2 Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.1,2 This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.1,2

1.Zemski Berry, K.A., Turner, W.W., VanNieuwenhze, M.S., et al.Stable isotope labeled 4-(dimethylamino)benzoic acid derivatives of glycerophosphoethanolamine lipidsAnalytical Chemistry81(16)6633-6640(2009) 2.Zemski Berry, K.A., Turner, W.W., VanNieuwenhze, M.S., et al.Characterization of oxidized phosphatidylethanolamine derived from RAW 264.7 cells using 4-(dimethylamino)benzoic acid derivativesEur.J.Mass Spectrom16(3)463-470(2010)

Chemical Properties

Cas No. 1175002-03-5 SDF
别名 4(dimethylamino) Benzoic Acidd4, DMABA Nhydroxysuccinimide esterd4, NSuccinimidyl 4(dimethylamino)benzoated4
Canonical SMILES O=C(CC1)N(OC(C2=C([2H])C([2H])=C(N(C)C)C([2H])=C2[2H])=O)C1=O
分子式 C13H10D4N2O4 分子量 266.3
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.7552 mL 18.7758 mL 37.5516 mL
5 mM 0.751 mL 3.7552 mL 7.5103 mL
10 mM 0.3755 mL 1.8776 mL 3.7552 mL
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