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Dimethyl DL-Glutamate (hydrochloride) Sale

(Synonyms: DL-谷氨酸二甲酯盐酸盐,Glutamic Acid dimethyl ester,Dimethyl 2-aminopentanedioate) 目录号 : GC15286

A cell-permeant glutamate derivative

Dimethyl DL-Glutamate (hydrochloride) Chemical Structure

Cas No.:13515-99-6

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5g
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25g
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50g
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Dimethyl DL-glutamate is a cell-permeable form of glutamate.

Extracellular glutamic acid is an excitatory neurotransmitter, while intracellular glutamic acid is an amino acid that serves various metabolic roles.

In vitro: Dimethyl DL-glutamate at 3.0-10.0 mM could enhance insulin release evoked by 6.0-8.3 mM D-glucose, 1.0-10.0 mM L-leucine, or 5.0-10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and D-glucose concentration. Moreover, dimethyl DL-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of D-glucose. In islets exposed to L-leucine, the insulinotropic action of dimethyl DL-glutamate coincided with an early fall and later increase in 86Rb outflow. In addition, the overall gain in O2 uptake represented the balance between dimethyl DL-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous D-glucose [1].

In vivo: Dimethyl DL-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. Results showed that dimethyl DL-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of GLP-1 injected intravenously at min 5 of the test [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Sener, A. ,Conget, I.,Rasschaert, J., et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology 267(4 Pt 1), E573-E584 (1994).
[2] Cancelas, J. ,Villaneuva-Peacarrillo, M.L.,Valverde, I., et al. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. Endocrine 16(2), 113-116 (2001).

Chemical Properties

Cas No. 13515-99-6 SDF
别名 DL-谷氨酸二甲酯盐酸盐,Glutamic Acid dimethyl ester,Dimethyl 2-aminopentanedioate
化学名 1,5-dimethyl ester glutamic acid, monohydrochloride
Canonical SMILES COC(C(N)CCC(OC)=O)=O.Cl
分子式 C7H13NO4 • HCl 分子量 211.6
溶解度 ≤5mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.7259 mL 23.6295 mL 47.259 mL
5 mM 0.9452 mL 4.7259 mL 9.4518 mL
10 mM 0.4726 mL 2.3629 mL 4.7259 mL
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