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Diltiazem-d3 hydrochloride Sale

(Synonyms: 盐酸地尔硫卓 d3 (盐酸盐)) 目录号 : GC64299

Diltiazem-d3 hydrochloride 是 Diltiazem hydrochloride 的氘代物。Diltiazem hydrochloride是钙离子流入抑制剂(缓慢通道阻断剂或钙拮抗剂)。

Diltiazem-d3 hydrochloride Chemical Structure

Cas No.:1217623-80-7

规格 价格 库存 购买数量
5 mg
¥6,660.00
现货
10 mg
¥11,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Diltiazem-d3 hydrochloride is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.
[3]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.
[4]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.
[5]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.
[6]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author’s transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

Chemical Properties

Cas No. 1217623-80-7 SDF Download SDF
别名 盐酸地尔硫卓 d3 (盐酸盐)
分子式 C22H24D3ClN2O4S 分子量 454
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2026 mL 11.0132 mL 22.0264 mL
5 mM 0.4405 mL 2.2026 mL 4.4053 mL
10 mM 0.2203 mL 1.1013 mL 2.2026 mL
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