Deltorphin C (trifluoroacetate salt)
(Synonyms: Deltorphin I, D-Ala2Deltorphin) 目录号 : GC47184
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Deltorphin C is a peptide agonist of δ-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor.1 It is selective for δ-opioid receptors over µ- and ?-opioid receptors. It induces δ-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 µM, respectively, effects that can be blocked with the δ-opioid receptor antagonist naltrindole .2 Intrathecal administration of deltorphin C (0.15, 1.5, and 15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.3
1.Erspamer, V., Melchiorri, P., Falconieri-Erspamer, G., et al.Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sitesProc. Natl. Acad. Sci. USA86(13)5188-5192(1989) 2.Bao, L., Jin, S.-X., Zhang, C., et al.Activation of delta opioid receptors induces receptor insertion and neuropeptide secretionNeuron37(1)121-133(2003) 3.Labuz, D., Toth, G., Machelska, H., et al.Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: A search for selectivity of delta receptor subtypesNeuropeptides32(6)511-517(1998)
| Cas No. | N/A | SDF | |
| 别名 | Deltorphin I, D-Ala2Deltorphin | ||
| Canonical SMILES | OC1=CC=C(C[C@H](N)C(N[C@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)C=C1.OC(C(F)(F)F)=O | ||
| 分子式 | C37H52N8O10.XCF3COOH | 分子量 | 768.9 |
| 溶解度 | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL,Ethanol: 1mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3006 mL | 6.5028 mL | 13.0056 mL |
| 5 mM | 0.2601 mL | 1.3006 mL | 2.6011 mL |
| 10 mM | 0.1301 mL | 0.6503 mL | 1.3006 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。