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Clindamycin-d3 (hydrochloride) Sale

(Synonyms: 克林霉素-D3盐酸盐) 目录号 : GC52171

An internal standard for the quantification of clindamycin

Clindamycin-d3 (hydrochloride) Chemical Structure

Cas No.:1356933-72-6

规格 价格 库存 购买数量
500 µg
¥1,983.00
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1 mg
¥3,775.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Clindamycin-d3 is intended for use as an internal standard for the quantification of clindamycin by GC- or LC-MS. Clindamycin is a lincosamide antibiotic.1,2 It is active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively).1 Clindamycin is also active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively).2 It inhibits bacterial protein synthesis by interacting with the 50S ribosome.1 Clindamycin increases survival in a mouse model of a secondary S. pneumoniae infection when administered at a dose of 15 mg/kg twice daily for seven days.3 Formulations containing clindamycin have been used in the treatment of bacterial infections.

1.SpÍ?ek, J., and ?ezanka, T.Lincomycin, clindamycin and their applicationsAppl. Microbiol. Biotechnol.64(4)455-464(2004) 2.Dahl, E.L., and Rosenthal, P.J.Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplastAntimicrob. Agents Chemother.51(10)3485-3490(2007) 3.KarlstrÖm, Å., Boyd, K.L., English, B.K., et al.Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenzaJ. Infect. Dis.199(3)311-319(2009)

Chemical Properties

Cas No. 1356933-72-6 SDF Download SDF
别名 克林霉素-D3盐酸盐
Canonical SMILES O=C([C@@H]1C[C@H](CN1C([2H])([2H])[2H])CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C.Cl
分子式 C18H30D3ClN2O5S ? HCl 分子量 464.5
溶解度 DMSO: soluble,Water: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1529 mL 10.7643 mL 21.5285 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL
10 mM 0.2153 mL 1.0764 mL 2.1529 mL
464.5
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