CENPA Human
目录号 : GP23120着丝粒蛋白 A 人类重组
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Sf9 insect cells. |
| Phycical Appearance | Sterile Filtered liquid formulation. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Histone H3-like centromeric protein A; Centromere protein A; CENP-A; Centromere autoantigen A; CENPA. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles. | ||
| Formulation | CENPA is supplied in 20mM HEPES buffer pH-8, 100mM sodium chloride, and 6M Urea. | ||
Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENPA to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies.CENPA is another important centromeric autoantigen in addition to CENPB: it has a molecular weight of approx. 20 kDa and is incorporated into centromeric chromatin due to its histone-like properties. CENPA antibodies are an important marker for correct diagnosis of Scleroderma / CREST syndrome in CENPB-autoantibody negative patients.
Western-Blot with monoclonal anti-hexa-His-tag antibody & Scleroderma patient sera.
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles.