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Cefoselis Sale

(Synonyms: 头孢噻利) 目录号 : GC17728

A cephalosporin antibiotic

Cefoselis Chemical Structure

Cas No.:122841-10-5

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50mg
¥525.00
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产品描述

Cefoselis is a widely used antibiotic of β-lactam [1].

Cefoselis has a large antibacterial spectrum against gram positive bacterium. It is a 4th generation of cephalosporin. Cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. Through testing the dialysate and blood samples by HPLC, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. In renal failure rats, the elimination half-lives of cefoselis are prolonged. It may be one factor of the seizures caused by cefoselis. In addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of GABA, suggesting that cefoselis induces seizures through blocking the GABA receptors [1].

References:
[1] Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm. 2004 Dec;111(12):1523-35.

Chemical Properties

Cas No. 122841-10-5 SDF
别名 头孢噻利
化学名 (6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Canonical SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=C(N4CCO)N)C(=O)[O-]
分子式 C19H22N8O6S2 分子量 522.56
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 1.9137 mL 9.5683 mL 19.1366 mL
5 mM 0.3827 mL 1.9137 mL 3.8273 mL
10 mM 0.1914 mL 0.9568 mL 1.9137 mL
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