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CCT128930 hydrochloride Sale

目录号 : GC63539

An inhibitor of Akt2

CCT128930 hydrochloride Chemical Structure

Cas No.:2453324-32-6

规格 价格 库存 购买数量
5 mg
¥1,089.00
现货
10 mg
¥2,122.00
现货
50 mg
¥6,434.00
现货
100 mg
¥9,103.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

CCT128930 is an ATP-competitive inhibitor of Akt2 (IC50 = 6 nM).1 It is selective for Akt over a panel of 47 other kinases, including the related protein kinase A and p70S6K.1 CCT128930 blocks the phosphorylation of Akt targets, inhibits proliferation of multiple tumor cell lines in vitro, and prevents the growth of human tumor xenografts in mice.1 CCT128930 has been used to elucidate the role of Akt2 in regulating the function of interacting proteins, modulating DNA damage and autophagy in HepG2 hepatoma cells, and cell survival and vasculogenesis in endothelial colony forming cells.2,3,4

1.Yap, T.A., Walton, M.I., Hunter, L.J.K., et al.Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930Mol. Cancer Ther.10(2)360-371(2011) 2.Bottermann, K., Reinartz, M., Barsoum, M., et al.Systematic analysis reveals elongation factor 2 and α-enolase as novel interaction partners of AKT2PLoS One8(6)1-12(2013) 3.Wang, F.Z., Chang, Z.Y., Fei, H.R., et al.CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibitionBiochimie.103118-125(2014) 4.Kim, H., Prasain, N., Vemula, S., et al.Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matricesMicrovasc. Res.10172-81(2015)

Chemical Properties

Cas No. 2453324-32-6 SDF
分子式 C18H21Cl2N5 分子量 378.3
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6434 mL 13.217 mL 26.434 mL
5 mM 0.5287 mL 2.6434 mL 5.2868 mL
10 mM 0.2643 mL 1.3217 mL 2.6434 mL
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