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CAY10698 Sale

目录号 : GC43194

A selective inhibitor of 12-LO

CAY10698 Chemical Structure

Cas No.:684236-01-9

规格 价格 库存 购买数量
1mg
¥226.00
现货
5mg
¥1,020.00
现货
10mg
¥1,733.00
现货
25mg
¥3,569.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid . It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM. The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.

Chemical Properties

Cas No. 684236-01-9 SDF
Canonical SMILES COC1=C(O)C(CNC2=CC=C(S(NC3=NC=CS3)(=O)=O)C=C2)=CC=C1
分子式 C17H17N3O4S2 分子量 391.5
溶解度 DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.5 mg/ml 储存条件 4°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5543 mL 12.7714 mL 25.5428 mL
5 mM 0.5109 mL 2.5543 mL 5.1086 mL
10 mM 0.2554 mL 1.2771 mL 2.5543 mL
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