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Cannabidiol dimethyl ether Sale

(Synonyms: CBDD,Cannabidiol-2',6'-dimethyl ether) 目录号 : GC13816

Pomalidomide - Peg2-azide is a synthetic E3 ligand -linker conjugate containing Pomalidomide based cereblon ligand and 2-unit PEG linker.

Cannabidiol dimethyl ether Chemical Structure

Cas No.:1242-67-7

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1mg
¥444.00
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5mg
¥1,951.00
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10mg
¥3,426.00
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50mg
¥15,005.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Pomalidomide - Peg2-azide is a synthetic E3 ligand -linker conjugate containing Pomalidomide based cereblon ligand and 2-unit PEG linker. PROTAC can be synthesized to target protein degradation[1].

The IC50 value of protac compound 21[(BRD4 BD1, IC50 = 41.8 nM) composed of Pomalidomide - Peg2-azide] was 0.81 µM in inhibiting THP-1 cell line growth. At the concentration of 1 µM, compound 21 can effectively degrade BRD4 protein and inhibit c-Myc[1].

References:
[1]. Zhang F, Wu Z, et,al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. doi: 10.1016/j.bmc.2019.115228. Epub 2019 Nov 30. PMID: 31813613.

Chemical Properties

Cas No. 1242-67-7 SDF
别名 CBDD,Cannabidiol-2',6'-dimethyl ether
化学名 1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene
Canonical SMILES CCCCCc1cc(OC)c(c(OC)c1)[C@@H]1C=C(C)CCC1C(=C)C
分子式 C23H34O2 分子量 342.5
溶解度 ≤14mg/ml in ethanol;1mg/ml in DMSO;2mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9197 mL 14.5985 mL 29.1971 mL
5 mM 0.5839 mL 2.9197 mL 5.8394 mL
10 mM 0.292 mL 1.4599 mL 2.9197 mL
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Research Update

In vivo and in vitro metabolism of cannabidiol monomethyl ether and cannabidiol dimethyl ether in the guinea pig: on the formation mechanism of cannabielsoin-type metabolite from cannabidiol

Oxidative metabolism of cannabidiol monomethyl ether (CBDM), one of the components of marihuana, was studied in the guinea pig. Cannabielsoin monomethyl ether (CBEM) was found to be formed with hepatic microsomes by gas chromatography-mass spectrometry (GC-MS). Experiments using various modifiers of enzymatic reaction suggested that, as in the case of cannabielsoin (CBE) formation from canabidiol (CBD), CBEM was formed from CBDM by the monooxygenase system including cytochrome P450. When cannabidiol dimethyl ether (CBDD), in which phenolic hydroxyl groups of CBD are masked with methyl groups, was incubated with liver microsomes and an reduced nicotinamide adenine dinucleotide phosphate-generating system, 1S,2R-epoxy-CBDD was identified by GC-MS. The epoxy metabolite was also found in the liver of a guinea pig pretreated with CBDD (100 mg/kg, intraperitoneally) 1 h before sacrifice. Rate of 1S,2R-epoxide metabolism was slower than that of 1R,2S-epoxy-CBDD under the conditions, as in the microsomal oxidation of CBDD described above. These results indicate that 1S,2R-epoxides are formed from CBD, CBDM and CBDD and that the epoxides are quickly converted to elsoin-type metabolites in the cases of CBD and CBDM.