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BVD 10 Sale

目录号 : GC14393

NPY Y1 receptor antagonist,highly selective

BVD 10 Chemical Structure

Cas No.:262418-00-8

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1mg
¥1,659.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Ki: 25.7 nM for Y1

Neuropeptide Y (NPY), a 36-residue peptide amide isolated originally from porcine brain, is a member of homologous hormone family including peptide YY (PYY) and pancreatic polypeptide (PP). It is the most abundant peptide in the mammalian brain and has been shown to exhibit a wide spectrum of central and peripheral activities. These actions are mediated by at least six G-protein coupled receptor subtypes denoted as Y1, Y2, Y3, Y4, Y5, and y6. BVD 10 is a highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists.

In vitro: The inability to form such hydrogen bonding in BVD 10 may prevent or perturb the C-terminus reverse turn, which may contribute, at least in part, to the increased Y1 selectivity [1]. Moreover, BVD 10 and its NPY analogue peptide BVD15 were characterized conformationally. The two peptides exhibit different secondary structure characteristics in trifluoroethanol. Molecular modeling studies suggested that the C-terminus Tyr9 is oriented in different directions in the two peptides. The difference in the structures observed may contribute to the Y1 selectivity of BVD 10 relative to BVD 15 [2].

In vivo: No animal in vivo data have been reported so far.

Clinical trial: Up to now, BVD 10 is still in the preclinical development stage.

References:
[1] Balasubramaniam A, Dhawan VC, Mullins DE, Chance WT, Sheriff S, Guzzi M, Prabhakaran M, Parker EM.  Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90). J Med Chem. 2001 May 10;44(10):1479-82.
[2] Jois SD, Balasubramaniam A.  Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides. 2003 Jul;24(7):1035-43.

Chemical Properties

Cas No. 262418-00-8 SDF
化学名 (S,Z)-1-((S)-2-((Z)-((2S,3S)-2-amino-1-hydroxy-3-methylpentylidene)amino)-4-hydroxy-4-iminobutanoyl)-N-((4S,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,19S,20S)-7,13-bis(3-guanidinopropyl)-6,9,12,15,18-pentahydroxy-4,16-bis(4-hydroxybenzyl)-10-isobutyl-20-methyl-3-o
Canonical SMILES CC[C@]([C@@](N)([H])/C(O)=N/[C@@](C(N1CCC[C@@]1([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(OC)=O)([H])CC2=CC=C(O)C=C2)([H])CCCNC(N)=N)([H])CC(C)C)([H])CCCNC(N)=N)([H])CC3=CC=C(O)C=C3)([H])[C@@](CC)([H])C)=O)(
分子式 C58H92N16O13 分子量 1221.46
溶解度 Soluble to 1 mg/ml in Water 储存条件 Desiccate at -20°C
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1 mM 0.8187 mL 4.0935 mL 8.1869 mL
5 mM 0.1637 mL 0.8187 mL 1.6374 mL
10 mM 0.0819 mL 0.4093 mL 0.8187 mL
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