Bronopol (BNPD)
(Synonyms: 溴硝醇; BNPD; BNPK) 目录号 : GC30921
Bronopol (2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry.
Cas No.:52-51-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bronopol (2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry.
| Cas No. | 52-51-7 | SDF | |
| 别名 | 溴硝醇; BNPD; BNPK | ||
| Canonical SMILES | OCC([N+]([O-])=O)(Br)CO | ||
| 分子式 | C3H6BrNO4 | 分子量 | 199.99 |
| 溶解度 | DMSO : ≥ 31 mg/mL (155.01 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.0003 mL | 25.0013 mL | 50.0025 mL |
| 5 mM | 1.0001 mL | 5.0003 mL | 10.0005 mL |
| 10 mM | 0.5 mL | 2.5001 mL | 5.0003 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Biocidal control of legionellae
This paper examines the use of biocides to control the growth of Legionella pneumophila in recirculating cooling-water systems. The reasons for using biocides and their ideal properties are discussed. Comparative studies on several biocides' activity against Legionella are reported together with more detailed laboratory and field studies on one specific biocide, 2-bromo-2-nitropropane-1,3-diol (BNPD). The laboratory data include biocidal and biostatic tests on a range of Legionella species as well as the use of model cooling-water systems. The field studies comprise bacterial counts, fungal counts, Legionella isolation and chemical monitoring of biocide levels. BNPD was effective both in the laboratory and cooling-tower studies. In line with ecological considerations the activity of biocides against specific organisms implicated in supporting the growth of L. pneumophila is stressed. The paper emphasizes the need for field trial data to support laboratory studies in this area of biocide use.
Allergic contact dermatitis to 2-bromo-2-nitropropane-1,3-diol in a hydrophilic ointment
Seven patients are described who developed acute allergic contact dermatitis after using Eucerin cream on previously dermatitic skin for periods of time varying from 5 weeks to 2 years. Eucerin was preserved with 2-bromo-2-nitropropane-1,3-diol (BNPD) in 1978 to assist in controlling a problem with Pseudomonas aeruginosa contamination. All of our patients were BNPD and Eucerin patch test-positive. None of them was allergic to formaldehyde or to any other preservative known to be a formaldehyde donor. This was in contrast to other BNPD and other formaldehyde-releaser--sensitive patients we saw in 1979-1980, who often had positive patch test reactions throughout this group of preservatives. BNPD is difficult to patch test with because it is often an irritant, even in low concentrations. We discuss some patch test "lessons" which our experiences with these patients accentuated for us.