Bitoscanate (p-Phenylene diisothiocyanate)
(Synonyms: 对苯二异硫氰酸酯,p-Phenylene diisothiocyanate; 1,4-Diisothiocyanatobenzene; PDITC) 目录号 : GC32239
Bitoscanate (p-Phenylene diisothiocyanate) (p-Phenylene diisothiocyanate) 是一种用于治疗钩虫的有机化合物。
Cas No.:4044-65-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bitoscanate (p-Phenylene diisothiocyanate) is an organic chemical compound used in the treatment of hookworms.
[1]. Gaitonde BB, et al. Clinical evaluation of a new anthelmintic; phenylene di-iso thiocyanate (Bitoscanate) in hookworm and roundworm infestation. J Trop Med Hyg. 1969 Oct;72(10):253-8.
| Cas No. | 4044-65-9 | SDF | |
| 别名 | 对苯二异硫氰酸酯,p-Phenylene diisothiocyanate; 1,4-Diisothiocyanatobenzene; PDITC | ||
| Canonical SMILES | S=C=NC1=CC=C(N=C=S)C=C1 | ||
| 分子式 | C8H4N2S2 | 分子量 | 192.26 |
| 溶解度 | DMSO : 20 mg/mL (104.03 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2013 mL | 26.0064 mL | 52.0129 mL |
| 5 mM | 1.0403 mL | 5.2013 mL | 10.4026 mL |
| 10 mM | 0.5201 mL | 2.6006 mL | 5.2013 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Rapid DNA detection using filter paper
N Biotechnol 2020 Mar 25;55:77-83.PMID:31622785DOI:10.1016/j.nbt.2019.10.005
Point-of-care (POC) detection is crucial in clinical diagnosis in order to provide timely and specific treatment. Combining polyamidoamine (PAMAM) dendrimer, p-Phenylene diisothiocyanate (PDITC) and superparamagnetic beads, a novel method to activate the surface of filter paper to bind DNA molecules has been developed. The method is based on the primary amination of the filter paper surface with PAMAM dendrimer, followed by generation of isothiocyanate groups via PDITC, and subsequent repetition of these two steps. Different parameters of the process have been optimized, including probe printing, preparation of target DNAs and detection. The result shows that, due to the highly porous structure of filter paper, high amounts of printed probes, target DNAs and magnetic beads can provide high signal intensities in the detection area via probe/target duplex formation. This method is suitable for rapid, specific and cost-efficient DNA detection on cellulose filter paper. It can be used as a POC device, in particular for diagnosis and treatment management of infectious diseases and identification of antimicrobial drug resistance genes.