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Biliverdin (technical grade) Sale

(Synonyms: 去氫膽紅素) 目录号 : GC49708

A bile pigment

Biliverdin (technical grade) Chemical Structure

Cas No.:114-25-0

规格 价格 库存 购买数量
5 mg
¥714.00
现货
10 mg
¥1,284.00
现货
25 mg
¥2,855.00
现货

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产品描述

Biliverdin is a porphyrin bile pigment and precursor in the biosynthesis of bilirubin .1,2 It is formed via oxidative catabolism of heme by heme oxygenase-1 (HO-1) and further reduced to bilirubin by biliverdin reductase. Biliverdin has antioxidant activity in oxygen radical absorbance capacity (ORAC) and Trolox equivalent absorbance capacity (TEAC) assays when used at concentrations greater than 0.5 µM.3

1.Liu, Y., MoËnne-Loccoz, P., Loehr, T.M., et al.Heme oxygenase-1, intermediates in verdoheme formation and the requirement for reduction equivalentsJ. Biol. Chem.272(11)6909-6917(1997) 2.Maines, M.D.The heme oxygenase system: A regulator of second messenger gasesAnnu. Rev. Pharmacol. Toxicol.37517-554(1997) 3.MÖlzer, C., Huber, H., Steyrer, A., et al.In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrrolesFree Radic. Res.46(11)1369-1377(2012)

Chemical Properties

Cas No. 114-25-0 SDF Download SDF
别名 去氫膽紅素
Canonical SMILES OC(CCC1=C(/C=C2C(CCC(O)=O)=C(C)C(/C=C3NC(C(C=C)=C\3C)=O)=N/2)NC(/C=C4NC(C(C)=C\4C=C)=O)=C1C)=O
分子式 C33H34N4O6 分子量 582.7
溶解度 DMSO: slightly,Methanol: slightly 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 1.7161 mL 8.5807 mL 17.1615 mL
5 mM 0.3432 mL 1.7161 mL 3.4323 mL
10 mM 0.1716 mL 0.8581 mL 1.7161 mL
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Research Update

Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human Biliverdin reductase

Clin Neurol Neurosurg 2017 Jul;158:72-76.PMID:28499219DOI:10.1016/j.clineuro.2017.05.003.

Objective: To assess oxidant and antioxidant status in patients with common brain tumors; namely meningiomas, low-grade gliomas (LGG) and high-grade gliomas (HGG) and to compare with normal brain tissues. Patients and methods: Almost nine biomarkers were measured in 59 brain tumors obtained during surgery and 15 normal brain tissues that were collected during autopsy. Results were compared between two groups. Results: In general, protein oxidation and lipid peroxidation increased while antioxidant capacity decreased significantly in tumors compared to the controls (p<0.05) and higher the grade of the tumor, higher the levels of oxidation and lower the anti-oxidation. Conclusions: Reactive oxygen species may play a crucial role in the pathogenesis of these common brain tumors. As the processes at the molecular level understood, targeted-treatment adjunct to surgical removal will be possible to cope with these devastating brain tumors.

Cyclobilirubin formation by in vitro photoirradiation with neonatal phototherapy light

Pediatr Int 2001 Jun;43(3):270-5.PMID:11380923DOI:10.1046/j.1442-200x.2001.01398.x.

Background: The main mechanism of phototherapy for neonatal hyperbilirubinemia is the production and excretion of (EZ)- and (EE)-cyclobilirubin (4E,15Z- and 4E,15E-cyclobilirubin). Thus, the clinical efficacy of the light source for phototherapy must be evaluated by cyclobilirubin formation from (ZZ)-bilirubin in in vitro photoirradiation. Methods: In the present study, we investigated the in vitro production pattern of bilirubin photoisomers by phototherapy light from the bilirubin-human serum albumin complex. Results: No clear difference was found in the curves relative to (ZZ)-bilirubin and its photoisomers under aerobic and anaerobic conditions. The ratio of (EZ)-cyclobilirubin to (ZZ)-bilirubin increased proportionately to the dose of irradiating light and no photoequilibrium state was observed analogous to that found in configurational photoisomerization. The concentration of (EZ)- and (EE)-cyclobilirubin increased proportionately with the grade of the percentage decrease in A(460 nm) from 0 to 23%. With a percentage decrease in A(460 nm) of 23% or more, the cyclobilirubin concentrations reached a steady state. The reason for this appears to be that the concentration of (ZZ)-bilirubin, a substrate for photoisomers, dropped below 1 mg/100 mL. Biliverdin was produced only in trace amounts. However, the absorption at 520--700 nm increased after a percentage decrease in A(460 nm) of more than 23%. Conclusions: The results of the present study show that little bilirubin photooxidation occurred with in vitro aerobic photoirradiation. Before the concentration of cyclobilirubin reaches a steady state, it is theoretically valid to use the percentage decrease in A(460 nm) for the evaluation of the clinical efficacy of the light source.