Home>>Peptides>>β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human))

β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) Sale

(Synonyms: Β-促黑激素(人),Beta-MSH (1-22) (human)) 目录号 : GC33693

β-黑素细胞刺激素 (MSH),人 (Beta-MSH (1-22) (human)),一种 22 残基肽,作为内源性黑皮质素 4 受体 (MC4-R) 激动剂。

β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) Chemical Structure

Cas No.:17908-57-5

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1mg
¥1,607.00
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5mg
¥4,820.00
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10mg
¥8,122.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.

β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2].

β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2].

[1]. Muceniece R, et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol. 2005 Dec;169(1-2):13-9. [2]. Harrold JA, et al. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24(3):397-405.

Chemical Properties

Cas No. 17908-57-5 SDF
别名 Β-促黑激素(人),Beta-MSH (1-22) (human)
Canonical SMILES Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
分子式 C118H174N34O35S 分子量 2660.92
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.3758 mL 1.879 mL 3.7581 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL
10 mM 0.0376 mL 0.1879 mL 0.3758 mL
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